1: 1-fluoro-2-(4-iodophenoxy)-benzene With n-butyllithium in tetrahydrofuran; water T=-78 - 20°C; pH=2 - 4; 0.166667 h; Inert atmosphere; 2: tri-isopropoxy-borane in tetrahydrofuran; water
参考文献
Principia Biopharma Inc.; Goldstein, David Michael
Patent: US8673925 B1, 2014 ;
Location in patent: Page/Page column 232 ;
1: (2-bromo-5-fluorophenyl)methanol With n-butyllithium; sodium hydride in diethyl ether T=-78°C; 2: tri-isopropoxy-borane in diethyl ether T=-78 - 20°C; 3: With sulfuric acid in diethyl ether pH=1; Further stages.;
参考文献
Gunasekera, Dinara S.; Gerold, Dennis J.; Aalderks, Nathan S.; Chandra, J. Subash; Maanu, Christiana A.; Kiprof, Paul; Zhdankin, Viktor V.; Reddy, M. Venkat Ram
Tetrahedron, 2007 , vol. 63, # 38 p. 9401 - 9405
1: 1-bromo-3-methyl-benzene With n-butyllithium in tetrahydrofuran; hexane T=-78 - -10°C; 2: tri-isopropoxy-borane in tetrahydrofuran; hexane T=-78 - 20°C;
参考文献
Lloyd, David G.; Hughes, Rosario B.; Zisterer, Daniela M.; Williams, D. Clive; Fattorusso, Caterina; Catalanotti, Bruno; Campiani, Giuseppe; Meegan, Mary J.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 23 p. 5612 - 5615
