1: o-bromo-α,α,α-trifluoromethoxybenzene With tert.-butyl lithium in tetrahydrofuran; hexanes T=-78°C; 0.75 h; 2: tri-isopropoxy-borane in tetrahydrofuran; hexanes T=-78 - 20°C; 16 h; 3: With hydrogenchloride; sodium hydroxide more than 3 stages;
参考文献
MERCK and CO., INC.
Patent: WO2004/83189 A1, 2004 ;
Location in patent: Page 33-34 ;
1: 2-methoxy-5-bromo-pyridine With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.5 h; 2: tri-isopropoxy-borane in tetrahydrofuran; hexane T=-78 - -20°C; 3: With hydrogenchloride; water in tetrahydrofuran; hexane pH=5;
参考文献
BAYER HEALTHCARE AG
Patent: WO2005/68436 A1, 2005 ;
Location in patent: Page/Page column 26 ;
