1: (4-bromo-2-methyl-phenyl)-propyl ether With n-butyllithium in tetrahydrofuran T=-78°C; 0.333333 h; 2: tri-isopropoxy-borane in tetrahydrofuran T=-78 - 20°C; 18.25 h; 3: With hydrogenchloride; water
1: 1-bromo-4-cyclopropyl-benzene With n-butyllithium in tetrahydrofuran; hexane; toluene T=-70°C; 0.5 h; 2: tri-isopropoxy-borane in tetrahydrofuran; hexane; toluene T=-70 - -20°C; 3: With hydrogenchloride; water in tetrahydrofuran; hexane; toluene
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2007/93610 A1, 2007 ;
Location in patent: Page/Page column 46-47 ;
