1: 2-bromo-3,4-dimethyl-2-cyclopenten-1-one ethylene ketal With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 1 h;
2: tri-isopropoxy-borane in tetrahydrofuran; hexane
T=-78 - -30°C; 2 h;
3: With hydrogenchloride in tetrahydrofuran; hexane; water
参考文献
LG CHEM, LTD
Patent: US2009/30221 A1, 2009 ;
Location in patent: Page/Page column 11 ;
1: With lithium diisopropyl amide in tetrahydrofuran; n-heptane; ethylbenzene
T=0°C; 3 h;
2: With hydrogenchloride; water in tetrahydrofuran; n-heptane; ethylbenzene
T=20°C; 1 h;
参考文献
Kyowa Hakko Kirin Co., Ltd.
Patent: EP2108642 A1, 2009 ;
Location in patent: Page/Page column 87 ;
1: 2-bromo-α-(ethenyl)benzenemethanol With sodium hydride in tetrahydrofuran
T=0°C; 1 h;
2: With n-butyllithium in tetrahydrofuran
T=-70°C; 1 h;
3: tri-isopropoxy-borane
参考文献
VERTEX PHARMACEUTICALS INCORPORATED; WANG, Tiansheng; HANZELKA, Brian; MUH, Ute; BEMIS, Guy; ZUCCOLA, Harmon, J.
Patent: WO2011/19405 A1, 2011 ;
Location in patent: Page/Page column 208 ;
WO 2011/019405 A1
1: 5-bromo-1-ethyl-1H-indazole With n-butyllithium in tetrahydrofuran; hexane
T=-60 - -10°C; 1.25 h;
2: tri-isopropoxy-borane in tetrahydrofuran; hexane
T=-60 - 20°C;
3: water With hydrogenchloride in tetrahydrofuran; hexane
1 h;
参考文献
BIOENERGENIX; MCCALL, John M.; ROMERO, Donna L.; KELLY, Robert C.
Patent: WO2012/119046 A2, 2012 ;
Location in patent: Page/Page column 80 ;
