6-甲氧基-3,4-二氢-2(1H)-喹啉酮合成路线 （共 11 条）
反应条件
potassium carbonate in acetone T=20°C; 16 h;
参考文献
Pfizer Products Inc.
Patent: EP1175417 B1, 2004 ;
Location in patent: Page 27 ;
反应条件
potassium carbonate; [pentamethylcyclopentadienylRhCl2]2 in acetone T=100°C; 20 h;
参考文献
Fujita, Ken-Ichi; Takahashi, Yoshinori; Owaki, Maki; Yamamoto, Kazunari; Yamaguchi, Ryohei
Organic Letters, 2004 , vol. 6, # 16 p. 2785 - 2788
反应条件
2,6-dimethyl-3,5-diacetyl-1,4-dihydropyridine; camphor-10-sulfonic acid; Ru(bpy)3Cl2*6H2O in tetrahydrofuran; N,N-dimethyl-formamide 16 h; Schlenk techniqueIrradiation; chemoselective reaction;
参考文献
Cismesia, Megan A.; Ischay, Michael A.; Yoon, Tehshik P.
Synthesis (Germany), 2013 , vol. 45, # 19 art. no. 3889, p. 2699 - 2705
反应条件
1: With hydrogen; acetic acid; palladium on activated charcoal T=20°C; 14 h; 2: With acetic acid T=70°C; 1 h;
参考文献
Iyobe; Uchida; Kamata; Hotel; Kusama; Harada
Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 7 p. 822 - 829
反应条件
potassium carbonate in N,N-dimethyl-formamide Ambient temperature;
参考文献
Anderson, Wayne K.; Heider, Arvela R.; Raju, Natarajan; Yucht, Jeffery A.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 11 p. 2097 - 2102
反应条件
2,2'-azo-bisisobutyronitrile; tri-n-butyl-tin hydride in dimethyl sulfoxide T=120°C;
参考文献
Zhou, Wang; Zhang, Liangren; Jiao, Ning
Tetrahedron, 2009 , vol. 65, # 10 p. 1982 - 1987
反应条件
titanium(III) chloride in tetrahydrofuran 1 h; Ambient temperature;
参考文献
Kodera; Watanabe; Imada; Murahashi
Bulletin of the Chemical Society of Japan, 1994 , vol. 67, # 9 p. 2542 - 1549
反应条件
sulfuric acid in methanol 3 h; Heating;
参考文献
Sakamoto, Takeshi; Hosoda, Isao; Kikugawa, Yasuo
Journal of Heterocyclic Chemistry, 1988 , vol. 25, p. 1279 - 1281
反应条件
1.1: 94 percent / Cs2CO3 / dimethylformamide / 72 h / 20 °C 2.1: 71 percent / piperidine; pyridine / 4 h / Heating 3.1: H2; AcOH / 10 percent Pd-C / 14 h / 20 °C 3.2: 88 percent / AcOH / 1 h / 70 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 49, # 7 p. 822 - 829
反应条件
1.1: 71 percent / piperidine; pyridine / 4 h / Heating 2.1: H2; AcOH / 10 percent Pd-C / 14 h / 20 °C 2.2: 88 percent / AcOH / 1 h / 70 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 49, # 7 p. 822 - 829
