6-羟基-3,4-二氢-2(1H)-喹诺酮合成路线 （共 31 条）
反应条件
AlCl3, aluminium chloride T=210°C; 0.166667 h; Neat (no solvent);
参考文献
Pfizer Products Inc.
Patent: EP1175417 B1, 2004 ;
Location in patent: Page 27 ;
反应条件
sodium borohydride in hydrogenchloride; N,N-dimethyl acetamide; water
参考文献
Mendelovici, Marioara; Pilarsky, Gideon; Nidam, Tamar; Dolitzky, Ben-Zion
Patent: US2002/32333 A1, 2002 ;
反应条件
ammonium formate on silica gel; zinc in carbon dioxide T=50°C; P=90009 Torr; Autoclaveliquid CO2;
参考文献
Dinesh, Bhima Reddy; Baba, A. Ramesha; Sankar, K. Udaya; Gowda, D. Channe
Journal of Chemical Research, 2008 , # 5 p. 287 - 288
反应条件
trifluoroacetic acid; bis-[(trifluoroacetoxy)iodo]benzene in chloroform T=20°C; 33 h;
参考文献
Itoh, Naoki; Sakamoto, Takeshi; Miyazawa, Etsuko; Kikugawa, Yasuo
Journal of Organic Chemistry, 2002 , vol. 67, # 21 p. 7424 - 7428
反应条件
aluminium trichloride in chlorobenzene T=120°C; Cyclization; 6 h;
参考文献
Chen, I.-Li; Wang, Tai-Chi; Chen, Yeh-Long; Tzeng, Cherng-Chyi
Journal of the Chinese Chemical Society, 2000 , vol. 47, # 1 p. 155 - 162
参考文献
Sobolov-Jaynes, Susan Beth
Patent: US2003/105124 A1, 2003 ;
反应条件
1: 75 percent / acetone / 1 h / Heating 2: 63 percent / AlCl3 / 24 h / 160 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 14 p. 3546 - 3560
反应条件
hydrogenchloride 0.5 h; Heating;
参考文献
Journal of Heterocyclic Chemistry, , vol. 25, p. 1279 - 1281
反应条件
1: 95 percent / aq. K2CO3 / acetone / 1 h / 0 °C 2: 4 percent / AlCl3 / chlorobenzene / 6 h / 120 °C View Scheme
参考文献
Journal of the Chinese Chemical Society, , vol. 47, # 1 p. 155 - 162
参考文献
Cui, Li-Jing; Xie, Zhi-Feng; Piao, Hu-Ri; Li, Gao; Chai, Kyu-Yun; Quan, Zhe-Shan
Biological and Pharmaceutical Bulletin, 2005 , vol. 28, # 7 p. 1216 - 1220
