6-羟基-3,4-二氢-2(1H)-喹诺酮合成路线 （共 31 条）
反应条件
aluminium trichloride durch Schmelzen;
参考文献
Chemische Berichte, , vol. 60, p. 861
反应条件
tetraphosphorus decasulfide; triethylamine in acetonitrile 4 h; Heating;
参考文献
Xie, Zhi-Feng; Chai, Kyu-Yun; Piao, Hu-Ri; Kwak, Kyung-Chell; Quan, Zhe-Shan
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 21 p. 4803 - 4805
反应条件
1: 74 percent / aq.85percent KOH / propan-2-ol / 18 h / Heating 2: 93 percent / hydrogen / 10percent Pd-C / methanol; acetic acid / 8 h / 60 - 70 °C / 1140 - 1520 Torr View Scheme
参考文献
Nishi; Tabusa; Tanaka; Shimizu; Nakagawa
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 3 p. 1140 - 1147
反应条件
potassium hydroxide in isopropyl alcohol 18 h; Heating;
参考文献
Nishi; Tabusa; Tanaka; Shimizu; Nakagawa
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 3 p. 1140 - 1147
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in ethanol T=75 - 80°C;
参考文献
WO2006/22488 A1, ;
Page/Page column 3 ;
反应条件
potassium carbonate in acetone T=20°C; 16 h;
参考文献
Pfizer Products Inc.
Patent: EP1175417 B1, 2004 ;
Location in patent: Page 27 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide Ambient temperature;
参考文献
Anderson, Wayne K.; Heider, Arvela R.; Raju, Natarajan; Yucht, Jeffery A.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 11 p. 2097 - 2102
反应条件
sodium hydroxide; potassium carbonate; sodium sulfite in water; isopropyl alcohol 6 h; Heating / reflux;
参考文献
OTSUKA PHARMACEUTICAL CO., LTD.
Patent: EP1489080 A1, 2004 ;
Location in patent: Page 6 ;
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in ethanol T=75 - 80°C;
参考文献
YUHAN CORPORATION
Patent: WO2006/22488 A1, 2006 ;
Location in patent: Page/Page column 3 ;
反应条件
1: 6-hydroxy-1,2,3,4-tetrahydro-2-quinolinone With potassium carbonate in water; acetone
T=20°C; 1 h;
2: 1,3-dibromo-propane in water; acetone
T=20°C; 16 h;
参考文献
Pai; Samel
Asian Journal of Chemistry, 2011 , vol. 23, # 4 p. 1655 - 1660
