6-羟基-3,4-二氢-2(1H)-喹诺酮合成路线 （共 31 条）
反应条件
2,6-dimethylpyridine; tetrabutyl-ammonium chloride; potassium carbonate in water
8 h; Heating;
参考文献
Aki, Shinji; Nishi, Takao; Minamikawa, Jun-Ichi
Chemistry Letters, 2004 , vol. 33, # 7 p. 940 - 941
反应条件
sodium hydroxide in methanol
参考文献
Wei, Cheng-Xi; Deng, Xian-Qing; Chai, Kyu-Yun; Sun, Zhi-Gang; Quan, Zhe-Shan
Archives of Pharmacal Research, 2010 , vol. 33, # 5 p. 655 - 662
反应条件
potassium hydroxide in ethanol
5 h; Reflux;
参考文献
Meiring, Letitia; Petzer, Jacobus P.; Petzer, Anel
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 20 p. 5498 - 5502
反应条件
sodium hydroxide in ethanol
2.5 h; Heating;
参考文献
Cui, Li-Jing; Xie, Zhi-Feng; Piao, Hu-Ri; Li, Gao; Chai, Kyu-Yun; Quan, Zhe-Shan
Biological and Pharmaceutical Bulletin, 2005 , vol. 28, # 7 p. 1216 - 1220
反应条件
sodium hydroxide in methanol
参考文献
Wei, Cheng-Xi; Deng, Xian-Qing; Chai, Kyu-Yun; Sun, Zhi-Gang; Quan, Zhe-Shan
Archives of Pharmacal Research, 2010 , vol. 33, # 5 p. 655 - 662
反应条件
1: 66 percent / aq.85percent KOH / propan-2-ol / 18 h / Heating
2: 88 percent / hydrogen / 10percent Pd-C / methanol; acetic acid / 8 h / 60 - 70 °C / 1140 - 1520 Torr
View Scheme
参考文献
Nishi; Tabusa; Tanaka; Shimizu; Nakagawa
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 3 p. 1140 - 1147
反应条件
potassium hydroxide in isopropyl alcohol
4 h; Heating;
参考文献
Nishi; Tabusa; Tanaka; Shimizu; Kanbe; Kimura; Nakagawa
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 4 p. 1151 - 1157
反应条件
N-benzyl-trimethylammonium hydroxide
3 h; Heating;
参考文献
Nishi; Yamamoto; Shimizu; Kanbe; Kimura; Nakagawa
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 3 p. 798 - 810
反应条件
1: 72 percent / NaOH / dimethylformamide / 1.) 1 h, r.t., 2.) 3 h, 40-45 deg C
2: 87.4 percent / NaOH / methanol / 1.5 h / Heating
3: 85 percent / 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) / dioxane / 15 h / Heating
View Scheme
参考文献
Nishi; Yamamoto; Shimizu; Kanbe; Kimura; Nakagawa
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 3 p. 798 - 810
反应条件
sodium hydroxide in N,N-dimethyl-formamide
1.) 1 h, r.t., 2.) 3 h, 40-45 deg C;
参考文献
Nishi; Yamamoto; Shimizu; Kanbe; Kimura; Nakagawa
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 3 p. 798 - 810
