1: bis-(2,2-diethoxy-ethyl) ether With acetic acid in water T=100°C; 2 h; 2: acetone-1,3-dicarboxylic acid; benzylamine With disodium hydrogenphosphate; citric acid in water T=25 - 28°C; 24 h; 3: With sodium hydroxide in water pH=11;
参考文献
PURDUE PHARMA L.P.; SHIONOGI and CO., LTD.
Patent: WO2009/27820 A2, 2009 ;
Location in patent: Page/Page column 322-323 ;
WO 2009/027820 A2