反应条件
1: 1-[(dimethylamino)methyl]-imidazole With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.5 h; Inert atmosphere; 2: With N,N'-dimethyl-N,N'-propyleneurea in tetrahydrofuran; hexane T=-70°C; 0.5 h; Inert atmosphere; 3: 1-iodo-butane in tetrahydrofuran; hexane T=-78 - 20°C; 16 h; Inert atmosphere; regiospecific reaction;
参考文献
Agelis, George; Resvani, Amalia; Koukoulitsa, Catherine; Tumova, Tereza; Slaninova, Jirina; Kalavrizioti, Dimitra; Spyridaki, Katerina; Afantitis, Antreas; Melagraki, Georgia; Siafaka, Athanasia; Gkini, Eleni; Megariotis, Grigorios; Grdadolnik, Simona Golic; Papadopoulos, Manthos G.; Vlahakos, Demetrios; Maragoudakis, Michael; Liapakis, George; Mavromoustakos, Thomas; Matsoukas, John
European Journal of Medicinal Chemistry, 2013 , vol. 62, p. 352 - 370
