1: cyclopenta-1,3-diene With n-butyllithium in tetrahydrofuran; hexane
T=-78 - 20°C;
2: methyl chloroformate in tetrahydrofuran; hexane
Further stages.;
参考文献
Scapens, David; Adams, Harry; Johnson, Tony R.; Mann, Brian E.; Sawle, Philip; Aqil, Rehan; Perrior, Trevor; Motterlini, Roberto
Dalton Transactions, 2007 , # 43 p. 4962 - 4973
sulfuric acid; sodium
1.) xylene, 2-propanol, 3.) neat, distillation at 160-190 deg C / 10 Torr; Multistep reaction. Title compound not separated from byproducts;
1: 85 percent / ZnBr2 / 1 h at O deg C, then 1 h at room temp.
2: 99 percent / H2 / 10percent Pd on C / diethyl ether / 2 h
3: 95 percent / diethyl ether / 2 h / -78 °C
4: 76 percent / BF3*2AcOH / CH2Cl2 / 0.25 h / 0 °C
View Scheme
参考文献
Fleming, Ian; Patel, Shailesh K.; Urch, Christopher J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1989 , p. 115 - 124
