反应条件
1: 69 percent / hydrogen chloride / -35 °C 2: 1) magnesium / 1) THF, -12 to -7 deg C, 1 h, 2) to room temperature, overnight 3: 68 percent / lithium aluminum hydride / diethyl ether / 0.5 h / 0 °C 4: 98 percent / triethylamine, DMAP / CH2Cl2 / 0 deg C to room temperature, overnight 5: 1) dibromodimethylhydantoin, 2) potassium carbonate / 1) acetone, water, 0 deg C, 2) methanol, room temperature, overnight 6: 84 percent / sodium azide, ammonium chloride / aq. ethanol / 72 h / 100 °C 7: 21 percent / diethylaminosulphur trifluoride / CH2Cl2 / 0.17 h / 0 °C 8: 99 percent / H2 / Lindlar / ethanol / 3 h / 760 Torr / Ambient temperature 9: 82 percent / dimethylformamide / Ambient temperature; overnight 10: 89 percent / p-toluenesulphonic acid / CH2Cl2; methanol / 3 h / Ambient temperature 11: 88 percent / aq. hydrochloric acid / 0.5 h / Heating View Scheme
参考文献
Coe, Diane M.; Parry, David M.; Roberts, Stanley M.; Storer, Richard
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , # 10 p. 2373 - 2378
