1.1: 54.3 percent / 30 percent H2O2; (CF3)2CO*3H2O; Na2HPO4 / CH2Cl2 / 7.5 h / 4 °C 2.1: Mg; I2; dibromoethane / tetrahydrofuran / 1.5 h 2.2: 76 percent / CuCl / tetrahydrofuran / 1 h / 20 °C 3.1: 88 percent / aq. H2SO4 / ethanol / 1 h / Heating 4.1: 68 percent / p-TsOH / CH2Cl2 / 0.33 h / 0 °C View Scheme

1.1: 54.3 percent / 30 percent H2O2; (CF3)2CO*3H2O; Na2HPO4 / CH2Cl2 / 7.5 h / 4 °C 2.1: Mg; I2; dibromoethane / tetrahydrofuran / 1.5 h 2.2: 76 percent / CuCl / tetrahydrofuran / 1 h / 20 °C 3.1: 88 percent / aq. H2SO4 / ethanol / 1 h / Heating View Scheme

Multi-step reaction with 2 steps 1.1: 54.3 percent / 30 percent H2O2; (CF3)2CO*3H2O; Na2HPO4 / CH2Cl2 / 7.5 h / 4 °C2.1: Mg; I2; dibromoethane / tetrahydrofuran / 1.5 h2.2: 76 percent / CuCl / tetrahydrofuran / 1 h / 20 °C  

Multi-step reaction with 3 steps 1: 50 percent / hexafluoroacetone trihydrate, 30 wt percent aq. H2O2 / CH2Cl2 / 4 °C2: 1.) Mg, 2.) CuCl, 4.) aq. NH4Cl3: 10 percent aq. H2SO4 / ethanol / 1 h / Heating