2-溴-5-羟基-3-甲基吡啶合成路线 （共 9 条）
反应条件
hydrogenchloride; sodium nitrite in water T=0 - 90°C; 0.833333 h;
参考文献
WO2005/123668 A1, ;
Page/Page column 46-47 ;
WO 2005/123668 A1
参考文献
Abbott Laboratories
Patent: US6133253 A1, 2000 ;
反应条件
sodium hydroxide; acetic acid; sodium nitrite in hydrogenchloride; water
反应条件
dihydrogen peroxide in dichloromethane T=20°C; 12 h;
参考文献
Fontaine, Fanny; Hequet, Arnaud; Voisin-Chiret, Anne-Sophie; Bouillon, Alexandre; Lesnard, Aurelien; Cresteil, Thierry; Jolivalt, Claude; Rault, Sylvain
Journal of Medicinal Chemistry, 2014 , vol. 57, # 6 p. 2536 - 2548
反应条件
hydrogenchloride; HPF6; sodium nitrite Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Journal of Heterocyclic Chemistry, , vol. 17, p. 445 - 448
反应条件
NaH in N,N-dimethyl-formamide
参考文献
Merck and Co., Inc.
Patent: US4374140 A1, 1983 ;
US 4374140 A
反应条件
sodium hydride in N,N-dimethyl-formamide
Ambient temperatureovernight;
参考文献
Ponticello, Gerald S.; Engelhardt, Edward L.; Freedman, Mark B.; Baldwin, John J.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 445 - 448
反应条件
1: 95 percent / NaH / dimethylformamide / Ambient temperature; overnight
2: 35 percent / KMnO4 / H2O / 1 h / Heating
View Scheme
参考文献
Ponticello, Gerald S.; Engelhardt, Edward L.; Freedman, Mark B.; Baldwin, John J.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 445 - 448
反应条件
1: 95 percent / NaH / dimethylformamide / Ambient temperature; overnight
2: 35 percent / KMnO4 / H2O / 1 h / Heating
3: SOCl2 / 3 h / Heating
4: NH3*H2O / 0.25 h / 0 - 4 °C
5: 86 percent / triflic anhydride/triphenylphosphine oxide / CH2Cl2 / Ambient temperature; overnight
6: 70 percent / pyridine hydrochloride / 2 h / 200 °C
View Scheme
参考文献
Ponticello, Gerald S.; Engelhardt, Edward L.; Freedman, Mark B.; Baldwin, John J.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 445 - 448
