2,4-二氯-6-甲基嘧啶合成路线 （共 66 条）
参考文献
Gabriel; Colman
Chemische Berichte, 1899 , vol. 32, p. 2934
Chemische Berichte, 1902 , vol. 35, p. 1570
反应条件
N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=20°C;
参考文献
Baumann, Karlheinz; Flohr, Alexander; Goetschi, Erwin; Jacobsen, Helmut; Jolidon, Synese; Luebbers, Thomas
Patent: US2009/215759 A1, 2009 ;
Location in patent: Page/Page column 49 ;
反应条件
2,3,11,12-dicyclohexano-1,4,7,10,13,16-hexaoxacyclo-octadecane; potassium fluoride in various solvent(s)
T=150°C;
参考文献
Svirskaya, Polina I.; Yedidia, Varda; Leznoff, Clifford C.; Miller, Jack M.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 149 - 153
参考文献
Pfleiderer; Mosthaf
Chemische Berichte, 1957 , vol. 90, p. 738,745
反应条件
2: N-bromosuccinimide
View Scheme
参考文献
Kanatomo; Wada; Yomei; Hase; Nagai; Fukuda; Tanaka; Sasaki
Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 6 p. 2042 - 2049
反应条件
potassium hydroxide in water
T=20°C; 6 h;
参考文献
CORNELL UNIVERSITY; COFERON, INC.; PURDUE RESEARCH FOUNDATION
Patent: US2012/295874 A1, 2012 ;
Location in patent: Page/Page column 197 ;
US 20120295874 A1
参考文献
Andrisano
Bollettino Scientifico della Facolta di Chimica Industriale di Bologna, 1944 , vol. 5, p. 48,51
反应条件
methanol
Unter Kuehlung;
参考文献
Gabriel; Colman
Chemische Berichte, 1899 , vol. 32, p. 2934
Chemische Berichte, 1902 , vol. 35, p. 1570
反应条件
1: alcohol; ammonia / im Rohr
View Scheme
参考文献
Gabriel; Colman
Chemische Berichte, 1899 , vol. 32, p. 2934
Chemische Berichte, 1902 , vol. 35, p. 1570
反应条件
1: 2,4-dichloro-6-methyl-pyrimidine With lithium diisopropyl amide in tetrahydrofuran
T=-78°C; 0.583333 h;
2: methyl iodide in tetrahydrofuran
T=-78°C; 3 h;
参考文献
Erickson, Shawn David; Baldwin, John J.; Dolle III, Roland Ellwood; Inglese, James; Ohlmeyer, Michael H.J.; Ho, Koc-Kan; Bohnstedt, Adolph C.; Kultgen, Steven G.; Conti, Paolo Giovanni Martino; Leysen, Dirk; van der Louw, Jaap
Patent: US2004/87601 A1, 2004 ;
Location in patent: Page 29 ;
US 20040087601 A1
