2,4-二氯-6-甲基嘧啶合成路线 （共 66 条）
参考文献
Yanai; Naito
Yakugaku Zasshi, 1941 , vol. 61, p. 99,105; dtsch. Ref. S. 46, 52
Chem.Abstr., 1942 , p. 479
参考文献
Yanai; Naito
Yakugaku Zasshi, 1941 , vol. 61, p. 99,105; dtsch. Ref. S. 46, 52
Chem.Abstr., 1942 , p. 479
反应条件
sodium
1.) toluene, 0 deg C, 2 h; 2.) reflux, 16 h; Yield given. Multistep reaction;
参考文献
Hung; Werbel
Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 3 p. 741 - 744
反应条件
1: alcohol; ammonia / im Rohr
2: alcohol; potassium hydrosulfide / 100 °C / im Rohr
View Scheme
参考文献
Gabriel; Colman
Chemische Berichte, 1899 , vol. 32, p. 2934
Chemische Berichte, 1902 , vol. 35, p. 1570
反应条件
1: 1.) sodium; / 1.) toluene, 0 deg C, 2 h; 2.) reflux, 16 h
2: 94 percent / bromine / CH2Cl2 / 0 °C
View Scheme
参考文献
Hung; Werbel
Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 3 p. 741 - 744
反应条件
N-chloro-succinimide; dibenzoyl peroxide in tetrachloromethane
24 h; Heating / reflux;
参考文献
Guo, Hongyan; Kim, Choung U.; Kim, Hae Soo; Lee, Chong-Kyo; Lee, Ill Young; Mitchell, Michael L.; Son, Jong Chan; Xu, Lianhong
Patent: US2008/70920 A1, 2008 ;
Location in patent: Page/Page column 90 ;
反应条件
1: palladium/charcoal; MgO; aqueous ethanol / Hydrogenation
2: 165 °C
3: KOH / unter vermindertem Druck
View Scheme
参考文献
Overberger; Kogon
Journal of the American Chemical Society, 1954 , vol. 76, p. 1879,1882
反应条件
1: in tetrahydrofuran; water
T=20°C; 24 h;
2: With sodium hydrogencarbonate in tetrahydrofuran; water
参考文献
TAISHO PHARMACEUTICAL CO., LTD.; Arena Pharmaceuticals, Inc
Patent: WO2005/95357 A2, 2005 ;
Location in patent: Page/Page column 137; 138 ;
WO 2005/095357 A2
反应条件
in toluene
14 h; Heating;
参考文献
Copar, Anton; Stanovnik, Branko; Tisler, Miha
Journal of Heterocyclic Chemistry, 1996 , vol. 33, # 2 p. 465 - 474
反应条件
lithium perchlorate in diethyl ether
24 h;
参考文献
McCluskey, Adam; Keller, Paul A.; Morgan, Jody; Garner, James
Organic and Biomolecular Chemistry, 2003 , vol. 1, # 19 p. 3353 - 3361
