2-苯基-1,3-二噻烷合成路线 （共 88 条）
反应条件
1: 78 percent / n-BuLi / tetrahydrofuran / 1 h / -78 °C 2: 10.10 g / Raney-Ni / aq. ethanol / 2 h / Heating 3: 79 percent / 75percent H2SO4 / 8 h / 100 °C View Scheme
参考文献
Katsuura, K.; Snieckus, V.
Tetrahedron Letters, 1985 , vol. 26, # 1 p. 9 - 12
反应条件
1: 1) n-BuLi / 1) THF, hexane, -78 deg C, 2) -78 deg C to r.t., overnight 2: 54 percent / N-bromosuccinimide / acetone; H2O / 0.5 h / 5 deg C to r.t. View Scheme
参考文献
Page; Graham; Park
Tetrahedron, 1992 , vol. 48, # 35 p. 7265 - 7274
反应条件
1: NaIO4 / methanol 2: 50 percent / 565 °C / 0.05 Torr View Scheme
参考文献
Kabzinska, Krystyna; Kawecki, Robert
Bulletin of the Polish Academy of Sciences, Chemistry, 1989 , vol. 37, # 3-4 p. 117 - 121
反应条件
1: 1.) n-BuLi, 2.) D2O / 1.) THF, -60 - 70 deg C,6 h, 2.) -60 deg C -> room temperature 2: 80 percent / HgCl2, HgO / methanol; H2O / 4 h / Heating View Scheme
参考文献
Wong, Chi-Huey; Whitesides, George M.
Journal of the American Chemical Society, 1981 , vol. 103, # 16 p. 4890 - 4899
反应条件
sodium in various solvent(s) T=140°C; 5.5 h; var. solv. and temp.; Product distribution;
参考文献
Tetrahedron Letters, , vol. 39, # 18 p. 2671 - 2674
反应条件
1: 81.5 percent / 1.) n-butyllithium / 1.) THF, hexane, 1 h; 2.) -10 degC - -5 degC, 2.5 h 2: 77 percent / thallium(III) trifluoroacetate / 0.5 h / Ambient temperature View Scheme
参考文献
Ho, Tse-Lok; Hill, Raymond J.; Wong, C. M.
Heterocycles, 1988 , vol. 27, # 7 p. 1719 - 1726
反应条件
1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere 1.2: -78 - 20 °C 2.1: boron trifluoride diethyl etherate; mercury(II) oxide / tetrahydrofuran; water / 0 - 20 °C / Inert atmosphere 3.1: Pseudomonas stutzeri lipase / tetrahydrofuran / 50 °C / Inert atmosphere 3.2: 24 h / 50 °C / Inert atmosphere View Scheme
参考文献
Hoyos, Pilar; Pace, Vittorio; Sinisterra, Jose V.; Alcantara, Andres R.
Tetrahedron, 2011 , vol. 67, # 38 p. 7321 - 7329
反应条件
1: 63 percent / n-BuLi / tetrahydrofuran / -40 - 20 °C 2: 34 percent / propan-2-ol / Irradiation View Scheme
参考文献
Reddy, Anugula Mahipal; Tsutsui, Shinobu; Sakamoto, Kenkichi
Chemistry Letters, 2001 , # 5 p. 476 - 477
反应条件
1: 2-phenyl-1,3-dithiane With dibenzyl sulphoxide; bromine in chloroform T=20°C; 2: (2,4-dinitro-phenyl)-hydrazine
参考文献
Iranpoor, Nasser; Firouzabadi, Habib; Shaterian, Hamid Reza
Journal of Organic Chemistry, 2002 , vol. 67, # 9 p. 2826 - 2830
反应条件
1.1: BuLi / hexane; tetrahydrofuran / 2.5 h / -70 - -50 °C 1.2: tetrahydrofuran; hexane 2.1: N-chlorosuccinimide; AgNO3 / acetonitrile; H2O / 55 °C View Scheme
参考文献
Kandanarachchi, Pramod H; Autrey, Tom; Franz, James A
The Journal of organic chemistry, 2002 , vol. 67, # 23 p. 7937 - 7945
