2-苯基-1,3-二噻烷合成路线 （共 88 条）
反应条件
1: 1.) n-BuLi / 1.) TMEDA, -78 deg C, 2.) THF, -78 deg C, overnight 2: 77.7 percent / CF3COOH, 35 percent aq. CH2O / CHCl3 / 72 h / Ambient temperature View Scheme
参考文献
Yamamori, Teruo; Adachi, Ikuo
Tetrahedron Letters, 1980 , vol. 21, p. 1747 - 1750
反应条件
1: 58 percent / n-BuLi / tetrahydrofuran / -40 - 20 °C 2: 46 percent / Irradiation View Scheme
参考文献
Reddy, Anugula Mahipal; Tsutsui, Shinobu; Sakamoto, Kenkichi
Chemistry Letters, 2001 , # 5 p. 476 - 477
反应条件
water in 1,4-dioxane; water T=25°C; variation of metal ion concentration, ionic strength, temperature, and solvent ratio; MechanismRate constant;
参考文献
Satchell, Derek P. N.; Satchell, Rosemary S.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1987 , p. 513 - 516
反应条件
1: 99 percent Chromat. / nBuLi / tetrahydrofuran / 1.) 0 deg C, 30 min; 2.) room temp., 1 h 2: PhI(OC(O)CCl3)2 / acetonitrile; H2O / 0.08 h / Ambient temperature View Scheme
参考文献
Stowell, Michael H.B.; Rock, Ronald S.; Rees; Chan, Sunney I.
Tetrahedron Letters, 1996 , vol. 37, # 3 p. 307 - 310
反应条件
1: 2-phenyl-1,3-dithiane With n-butyllithium in tetrahydrofuran; hexane T=-23°C; Metallation; 1 h; 2: chloro-trimethyl-silane in tetrahydrofuran; hexane T=0°C; silylation; 1 h;
参考文献
Patrocinio, Amauri F.; Moran, Paulo J.S.
Journal of Organometallic Chemistry, 2000 , vol. 603, # 2 p. 220 - 224
反应条件
1: 1.) BuLi / 2.) Swern oxidation
2: Kagan oxidation
3: 58 percent / DIBAL / tetrahydrofuran / -78 °C
4: 12 percent / NBS, 3percent H2O / acetone / 0.02 h
View Scheme
参考文献
Page; Graham; Park
Tetrahedron, 1992 , vol. 48, # 35 p. 7265 - 7274
反应条件
1: 1.) n-butyllithium / 1.) THF, hexane, -78 deg C, 6 h, 2.) 25 deg C, 18 h
2: 65 percent / N-chlorosuccinimide, silver nitrate / acetonitrile / 1 h / 25 °C
View Scheme
参考文献
Padwa,A.; Rodriguez,A.; Tohidi,M.
Journal of the American Chemical Society, 1983 , vol. 105, p. 933
反应条件
1: 1.) BuLi / 2.) Swern oxidation
2: Kagan oxidation
3: Ambient temperature
4: NBS / acetone
View Scheme
参考文献
Page, Philip C. Bulman; Purdle, Mark; Lathbury, David
Tetrahedron Letters, 1996 , vol. 37, # 49 p. 8929 - 8932
反应条件
1: n-butyllithium / tetrahydrofuran
2: N-bromosuccinmide; water / acetone / 1 h / 20 °C
3: 20 °C
4: Pd0(tris(tert-butyl)phosphine)2; caesium carbonate / tetrahydrofuran; water / 60 °C
View Scheme
参考文献
Matsumoto, Kenji; Shindo, Mitsuru
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 4 p. 642 - 650
反应条件
1.1: n-BuLi / tetrahydrofuran; pentane / 2 h / 0 °C
1.2: 97 percent / tetrahydrofuran; pentane
2.1: 28 percent / chloramine-T hydrate / H2O; methanol / 0 - 20 °C
View Scheme
参考文献
Page, Philip C. Bulman; Rosenthal, Stephen
Journal of Chemical Research, Miniprint, 1990 , # 10 p. 2351 - 2363
