2-苯基-1,3-二噻烷合成路线 （共 88 条）
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -80 °C
1.2: 0.5 h / -80 - 0 °C
2.1: N-bromosuccinmide; water / acetone / 0.5 h / 20 °C / |Cooling with ice
View Scheme
参考文献
Kondo, Yasuhiro; Sasaki, Michiko; Kawahata, Masatoshi; Yamaguchi, Kentaro; Takeda, Kei
Journal of Organic Chemistry, 2014 , vol. 79, # 8 p. 3601 - 3609
反应条件
1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
1.2: -78 - 20 °C
2.1: boron trifluoride diethyl etherate; mercury(II) oxide / tetrahydrofuran; water / 0 - 20 °C / Inert atmosphere
View Scheme
参考文献
Kothapalli, Raveendra Babu; Niddana, Ramana; Balamurugan, Rengarajan
Organic Letters, 2014 , vol. 16, # 5 p. 1278 - 1281
反应条件
N-bromosuccinmide in dichloromethane
T=20°C; 0.0833333 h;
参考文献
Karimi, Babak; Seradj, Hassan; Maleki, Jafar
Tetrahedron, 2002 , vol. 58, # 22 p. 4513 - 4516
反应条件
boron trifluoride diethyl etherate; lead dioxide in tetrahydrofuran; water
0.5 h; Ambient temperature; Yields of byproduct given;
参考文献
Chamchaang, W.; Prankprakma, V.; Tarnchompoo, B.; Thebtaranonth, C.; Thebtaranonth, Y.
Synthesis, 1982 , # 7 p. 579 - 580
反应条件
1: 2-phenyl-1,3-dithiane With n-butyllithium in tetrahydrofuran; pentane
T=0°C;
2: triisopropylsilyl chloride in tetrahydrofuran; pentane
参考文献
Clayden, Jonathan; Watson, David W.; Chambers, Mark
Tetrahedron, 2005 , vol. 61, # 13 p. 3195 - 3203
反应条件
1: 2-phenyl-1,3-dithiane With n-butyllithium in tetrahydrofuran; hexane
T=0°C; 0.166667 h;
2: tri-isopropylsylil trifluoromethane sulfonate in tetrahydrofuran; hexane
T=0 - 20°C;
参考文献
Svarovsky, Serge A.; Taraban, Marc B.; Barchi Jr., Joseph J.
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 21 p. 3155 - 3161
反应条件
n-butyllithium
1) THF, -78 deg C, 2) -78 deg C up to r.t. overnight; Yield given. Multistep reaction;
参考文献
Chung, Sung Kee; Dunn, Larson B. Jr.
Journal of Organic Chemistry, 1984 , vol. 49, # 5 p. 935 - 939
反应条件
n-butyllithium
1) THF, -22 deg C, 2) 2 h; Yield given. Multistep reaction;
参考文献
Chung, Sung Kee; Dunn, Larson B. Jr.
Journal of Organic Chemistry, 1984 , vol. 49, # 5 p. 935 - 939
反应条件
1: 82 percent / n-BuLi / tetrahydrofuran / -20 °C
2: acetic acid / acetonitrile / Heating
View Scheme
参考文献
Hiemstra, H. C.; Bieraeugel, H.; Wijnberg, M.; Pandit, U. K.
Tetrahedron, 1983 , vol. 39, # 23 p. 3981 - 3986
反应条件
n-butyllithium in tetrahydrofuran; hexane
参考文献
Ortho Pharmaceutical Corporation
Patent: US4089876 A1, 1978 ;
