N-叔丁氧羰基-环丙基甘氨酸合成路线 （共 5 条）
反应条件
sodium hydroxide in 1,4-dioxane; water T=0 - 20°C; 0.5 h;
参考文献
ELI LILLY COMPANY
Patent: WO2003/84929 A1, 2003 ;
Location in patent: Page/Page column 10 ;
WO 03/084929 A1
反应条件
ruthenium trichloride; sodium periodate in tetrachloromethane; water; acetonitrile T=20°C; Inert atmosphere;
参考文献
Chinese Journal of Chemistry, , vol. 28, # 9 p. 1525 - 1528
反应条件
1: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere 2: sodium periodate; ruthenium trichloride / tetrachloromethane; water; acetonitrile / 20 °C / Inert atmosphere View Scheme
参考文献
Chinese Journal of Chemistry, , vol. 28, # 9 p. 1525 - 1528
反应条件
1: di-μ-chloro-bis(η4-1,5-cyclooctadiene)diiridium; O,O’-(S)-1,1’-(dinaphthyl-2,2’-diyl)-N,N’-di-(S,S)-1-(2-methoxyphenyl)ethylphosphoramidite; 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 5 h / 50 °C / Inert atmosphere 2: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere 3: sodium periodate; ruthenium trichloride / tetrachloromethane; water; acetonitrile / 20 °C / Inert atmosphere View Scheme
参考文献
Chinese Journal of Chemistry, , vol. 28, # 9 p. 1525 - 1528
反应条件
1: di-μ-chloro-bis(η4-1,5-cyclooctadiene)diiridium; O,O’-(S)-1,1’-(dinaphthyl-2,2’-diyl)-N,N’-di-(S,S)-1-(2-methoxyphenyl)ethylphosphoramidite; 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 5 h / 50 °C / Inert atmosphere 2: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere 3: sodium periodate; ruthenium trichloride / tetrachloromethane; water; acetonitrile / 20 °C / Inert atmosphere View Scheme
参考文献
Chinese Journal of Chemistry, , vol. 28, # 9 p. 1525 - 1528
