5-(3,4-二甲氧基-苯基)-[1,3,4]噻二唑-2-胺合成路线 （共 4 条）
反应条件
1: With trichlorophosphate
T=75°C; 1 h;
2: With water
T=20°C; 4 h; Reflux;
参考文献
Alegaon, Shankar G.; Alagawadi, Kallanagouda R.
Medicinal Chemistry Research, 2012 , vol. 21, # 6 p. 816 - 824
反应条件
(i) FeCl3*6H2O, EtOH, (ii) aq. NH3; Multistep reaction;
参考文献
Ranga Rao,V.; Srinivasan,V.R.
Indian Journal of Chemistry, 1970 , vol. 8, p. 509 - 513
反应条件
sodium hydroxide
pH=12;
参考文献
Labanauskas; Kalcas; Udrenaite; Gaidelis; Brukstus; Dauksas
Pharmazie, 2001 , vol. 56, # 8 p. 617 - 619
反应条件
1.1: ethanol; water / Heating
2.1: anhydrous iron chloride / water / 0.75 h / 90 °C
2.2: Heating
View Scheme
参考文献
Gupta, Ankur; Singh, Priya; Kamble, Bhagyashree; Kulkarni, Aditi; Chandrasekar, Moola Joghee Nanjan
Letters in Drug Design and Discovery, 2012 , vol. 9, # 7 p. 668 - 675
