2,4-二甲基-5-乙氧羰基-3-吡咯丙酸乙酯合成路线 （共 20 条）
参考文献
Journal of the Chemical Society, , p. 1430,1438
反应条件
1: With sodium hydroxide; water 3 h; Heating / reflux; 2: With hydrogenchloride; water T=60°C; pH=3.5;
参考文献
Sugen, Inc.
Patent: US6878733 B1, 2005 ;
Location in patent: Page/Page column 213-214 ;
US 6878733 B1
反应条件
1: 1) SO2Cl2, 2) H2O / 1a) THF, -15 deg C, 1 h, 1b) 0 deg C, 4 h, 2) RT, overnight 2: 10percent aq. NaOH / 3 h / Heating 3: 1) TFA / 1) TFA, EtOH, overnight, 2) RT, 48 h 4: 81 percent / 5 h / 180 °C / 2 Torr 5: POCl3 / diethyl ether / Ambient temperature 6: NaOH / H2O / 0.5 h / Heating View Scheme
参考文献
Xie, Meiqiang; Lightner, David A.
Tetrahedron, 1993 , vol. 49, # 11 p. 2185 - 2200
反应条件
1: 1.) SO2Cl2; 2.) NaOH 2: 98 percent / CF3CO2H 3: 81 percent / Heating View Scheme
参考文献
Xie, Meiqiang; Lightner, David A.
Tetrahedron, 1993 , vol. 49, # 11 p. 2185 - 2200
反应条件
1: Br2, K2CO3 / CH2Cl2; diethyl ether / 0.33 h / Ambient temperature 2: CH2Cl2; diethyl ether / 0.5 h / Ambient temperature 3: 1.) KOH, 2.) AcOH, O2 / 1.) aq. EtOH, reflux, 4 h, 2.) aq. EtOH, RT 4: sulfuric acid / 5 h View Scheme
参考文献
Cheng, Lingjiang; Ma, Jinshi
Organic Preparations and Procedures International, 1995 , vol. 27, # 2 p. 224 - 228
反应条件
1: sodium / 100 °C / 13 Torr 2: methanol; sodium 3: sodium / 100 °C / 13 Torr 4: methanol; sodium View Scheme
参考文献
Hayes et al.
Journal of the Chemical Society, 1958 , p. 3779,3782
反应条件
1: sodium / 100 °C / 13 Torr
2: methanol; sodium
View Scheme
参考文献
Hayes et al.
Journal of the Chemical Society, 1958 , p. 3779,3782
反应条件
1: Br2, K2CO3 / CH2Cl2; diethyl ether / 0.33 h / Ambient temperature
2: CH2Cl2; diethyl ether / 0.5 h / Ambient temperature
3: 1.) KOH, 2.) AcOH, O2 / 1.) aq. EtOH, reflux, 4 h, 2.) aq. EtOH, RT
View Scheme
参考文献
Cheng, Lingjiang; Ma, Jinshi
Organic Preparations and Procedures International, 1995 , vol. 27, # 2 p. 224 - 228
反应条件
sodium hydroxide in ethanol
20 h; Ambient temperature;
参考文献
Boiadjiev, Stefan E.; Lightner, David A.
Tetrahedron Asymmetry, 1997 , vol. 8, # 21 p. 3603 - 3615
反应条件
sodium hydroxide in ethanol
3 h; Heating;
参考文献
Shrout; Lightner
Synthesis, 1990 , # 11 p. 1062 - 1065
