3-(2,4-二甲基-5-羧基-1H-3-吡咯)丙酸合成路线 （共 4 条）
参考文献
Vestling
Journal of Biological Chemistry, 1940 , vol. 135, p. 623,626
反应条件
sodium hydroxide in ethanol
3 h; Heating;
参考文献
Shrout; Lightner
Synthesis, 1990 , # 11 p. 1062 - 1065
反应条件
1: 1) NaNO2; 2) Zn / 1) glac. CH3COOH, water, 0-14 deg C, 3 h, then room temp., overnight; 2) 65 deg C, 5 h
2: 81.5 percent / aq. NaOH / ethanol / 2 h / Heating
View Scheme
参考文献
Lightner, D. A.; Ma, J.-S.; Adams, T. C.; Franklin, R. W.; Landen, G. L.
Journal of Heterocyclic Chemistry, 1984 , vol. 21, p. 139 - 144
反应条件
1: acetic acid; bromine
2: citric acid
View Scheme
参考文献
Fischer; Froewis
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1931 , vol. 195, p. 49,59
