1: With triethylamine in tetrahydrofuran T=0°C; 1.25 h; 2: With sodium tetrahydroborate in tetrahydrofuran; water T=0 - 20°C; 20 h;
参考文献
Carruthers, Nicholas I.; Keith, John M.; Letavic, Michael A.; Shah, Chandravadan R.
Patent: US2006/287292 A1, 2006 ;
Location in patent: Page/Page column 26 ;
US 20060287292 A1
1: benzyl-methyl-amine With ethyl-α,α,α-trifluoroacetate T=0 - 22°C; 0.5 h; 2: (S)-2-[N-(t-butoxycarbonyl)amino]-3-(naphth-2-yl)-propionic acid With 4-methyl-morpholine in ethyl acetate T=-15°C; 0.25 h; 3: isobutyl chloroformate in ethyl acetate T=-15°C; 1 h;
参考文献
Prashad, Mahavir; Prasad, Kapa; Repic, Oljan; Blacklock, Thomas J.; Prikoszovich, Walter
Organic Process Research and Development, 1999 , vol. 3, # 6 p. 409 - 415
