2-(3-(苄氧基)-4-甲氧基苯基)乙酰氯合成路线 （共 14 条）
反应条件
sodium carbonate in dichloromethane; water T=20°C; 2 h;
参考文献
Ploypradith, Poonsakdi; Petchmanee, Thaninee; Sahakitpichan, Poolsak; Litvinas, Nichole D.; Ruchirawat, Somsak
Journal of Organic Chemistry, 2006 , vol. 71, # 25 p. 9440 - 9448
反应条件
1.1: sodium hydroxide / chloroform / 0 - 20 °C 2.1: trichlorophosphate / acetonitrile / 3 h / Reflux; Inert atmosphere 2.2: 20 °C / Inert atmosphere; Cooling with ice 3.1: palladium 10 on activated carbon; hydrogen; acetic acid / methanol / 16 h 4.1: berberine bridge enzyme; tris(hydroxymethyl)methylamine hydrochloride; magnesium chloride / toluene / 24 h / 40 °C / pH 9 / Darkness; Enzymatic reaction View Scheme
参考文献
Schrittwieser, Joerg H.; Resch, Verena; Wallner, Silvia; Lienhart, Wolf-Dieter; Sattler, Johann H.; Resch, Jasmin; MacHeroux, Peter; Kroutil, Wolfgang
Journal of Organic Chemistry, 2011 , vol. 76, # 16 p. 6703 - 6714
反应条件
1: diethyl ether; aqueous NaOH-solution; chloroform 2: phosphoryl chloride; toluene View Scheme
参考文献
Robinson; Sugasawa
Journal of the Chemical Society, 1931 , p. 3163,3168
Journal of the Chemical Society, 1933 , p. 280
反应条件
oxalyl dichloride in benzene
参考文献
Zein, Ahmed L.; Dakhil, Otman O.; Dawe, Louise N.; Georghiou, Paris E.
Tetrahedron Letters, 2010 , vol. 51, # 1 p. 177 - 180
反应条件
1: NaBH4, 0.5N aq. NaOH / tetrahydrofuran / 2.5 h / Ambient temperature
2: SOCl2 / tetrahydrofuran; dimethylformamide / 1 h / Ambient temperature
3: 18-crown-6 / acetonitrile / 7 h / Heating
4: aq. KOH / ethanol / 4 h / Heating
5: thionyl chloride / toluene / 2 h / 80 °C
View Scheme
参考文献
Nakazato, Atsuro; Ohta, Kohmei; Sekiguchi, Yoshinori; Okuyama, Shigeru; Chaki, Shigeyuki; Kawashima, Yutaka; Hatayama, Katsuo
Journal of Medicinal Chemistry, 1999 , vol. 42, # 6 p. 1076 - 1087
反应条件
1: K2CO3 / dimethylformamide / 5 h / 40 - 50 °C
2: NaBH4, 0.5N aq. NaOH / tetrahydrofuran / 2.5 h / Ambient temperature
3: SOCl2 / tetrahydrofuran; dimethylformamide / 1 h / Ambient temperature
4: 18-crown-6 / acetonitrile / 7 h / Heating
5: aq. KOH / ethanol / 4 h / Heating
6: thionyl chloride / toluene / 2 h / 80 °C
View Scheme
参考文献
Nakazato, Atsuro; Ohta, Kohmei; Sekiguchi, Yoshinori; Okuyama, Shigeru; Chaki, Shigeyuki; Kawashima, Yutaka; Hatayama, Katsuo
Journal of Medicinal Chemistry, 1999 , vol. 42, # 6 p. 1076 - 1087
反应条件
1: 18-crown-6 / acetonitrile / 7 h / Heating
2: aq. KOH / ethanol / 4 h / Heating
3: thionyl chloride / toluene / 2 h / 80 °C
View Scheme
参考文献
Nakazato, Atsuro; Ohta, Kohmei; Sekiguchi, Yoshinori; Okuyama, Shigeru; Chaki, Shigeyuki; Kawashima, Yutaka; Hatayama, Katsuo
Journal of Medicinal Chemistry, 1999 , vol. 42, # 6 p. 1076 - 1087
反应条件
1: aq. KOH / ethanol / 4 h / Heating
2: thionyl chloride / toluene / 2 h / 80 °C
View Scheme
参考文献
Nakazato, Atsuro; Ohta, Kohmei; Sekiguchi, Yoshinori; Okuyama, Shigeru; Chaki, Shigeyuki; Kawashima, Yutaka; Hatayama, Katsuo
Journal of Medicinal Chemistry, 1999 , vol. 42, # 6 p. 1076 - 1087
反应条件
1: SOCl2 / tetrahydrofuran; dimethylformamide / 1 h / Ambient temperature
2: 18-crown-6 / acetonitrile / 7 h / Heating
3: aq. KOH / ethanol / 4 h / Heating
4: thionyl chloride / toluene / 2 h / 80 °C
View Scheme
参考文献
Nakazato, Atsuro; Ohta, Kohmei; Sekiguchi, Yoshinori; Okuyama, Shigeru; Chaki, Shigeyuki; Kawashima, Yutaka; Hatayama, Katsuo
Journal of Medicinal Chemistry, 1999 , vol. 42, # 6 p. 1076 - 1087
反应条件
1: K2CO3 / dimethylformamide / 5 h / 40 - 50 °C
2: NaBH4, 0.5N aq. NaOH / tetrahydrofuran / 2.5 h / Ambient temperature
3: SOCl2 / tetrahydrofuran; dimethylformamide / 1 h / Ambient temperature
4: 18-crown-6 / acetonitrile / 7 h / Heating
5: aq. KOH / ethanol / 4 h / Heating
6: thionyl chloride / toluene / 2 h / 80 °C
View Scheme
参考文献
Nakazato, Atsuro; Ohta, Kohmei; Sekiguchi, Yoshinori; Okuyama, Shigeru; Chaki, Shigeyuki; Kawashima, Yutaka; Hatayama, Katsuo
Journal of Medicinal Chemistry, 1999 , vol. 42, # 6 p. 1076 - 1087
