(3-苄氧基丙基)三苯基溴化鏻合成路线 （共 5 条）
反应条件
in toluene 7 h; Heating;
参考文献
Ziegler; Klein; Pati; Wang
Journal of the American Chemical Society, 1985 , vol. 107, # 9 p. 2730 - 2737
反应条件
1: 1.) methanesulfonyl chloride, triethylamine; 2.) lithium bromide / 1.) 30 min, 0 degC, CH2Cl2; 2.) acetone, 6 h, reflux 2: 85 percent / toluene / 7 h / Heating View Scheme
参考文献
Journal of the American Chemical Society, , vol. 107, # 9 p. 2730 - 2737
反应条件
1: With n-butyllithium in tetrahydrofuran Wittig reaction; 2: With hydrogen; palladium dihydroxide in methanol
参考文献
Lu, Xuequan; Bittman, Robert
Tetrahedron Letters, 2006 , vol. 47, # 5 p. 825 - 827
反应条件
1: n-butyllithium / tetrahydrofuran; hexane / 5 h / 25 °C
2: 67 g / concd. hydrochloric acid / methanol; diethyl ether / 20 h / 25 °C
3: 68 percent / pyridinium chlorochromate / CH2Cl2 / 8 h / 25 °C
View Scheme
参考文献
Ziegler; Klein; Pati; Wang
Journal of the American Chemical Society, 1985 , vol. 107, # 9 p. 2730 - 2737
反应条件
1.1: t-BuOK / tetrahydrofuran / 3 h / 70 °C
1.2: 2.17 g / tetrahydrofuran / 6 h / 70 °C
2.1: 1.31 g / H2 / 10 percent Pd/C / ethanol / 2585.74 Torr
View Scheme
参考文献
Ng, Howard P.; Karen, May; Bauman, John G.; Ghannam, Ameen; Islam, Imadul; Liang, Meina; Horuk, Richard; Hesselgesser, Joseph; Snider, R. Michael; Perez, H. Daniel; Morrissey, Michael M.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 22 p. 4680 - 4694
