2-(6-溴苯并[1,3]二氧杂环戊烯-5-基)乙腈合成路线 （共 14 条）
反应条件
18-crown-6 ether; potassium iodide in water; acetonitrile
10 h;
参考文献
MYRIAD GENETICS, INC.
Patent: WO2009/65035 A1, 2009 ;
Location in patent: Page/Page column 66 ;
反应条件
bromine in chloroform
T=0°C; 4 h; Darkness;
参考文献
Hsieh, Jen-Chieh; Cheng, An-Yi; Fu, Jun-Hao; Kang, Ting-Wei
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 31 p. 6404 - 6409
反应条件
in N,N-dimethyl-formamide
T=20°C;
参考文献
Kumar, Sarvesh; Peruncheralathan, Saravanan; Ila, Hiriyakkanavar; Junjappa, Hiriyakkanavar
Organic Letters, 2008 , vol. 10, # 5 p. 965 - 968
反应条件
in dimethyl sulfoxide
T=50 - 90°C; 0.333333 h;
参考文献
Kukosha, Tatyana; Trufilkina, Nadezhda; Katkevics, Martins
Synlett, 2011 , # 17 p. 2525 - 2528
反应条件
in N,N-dimethyl-formamide
T=20°C; Inert atmosphere;
参考文献
Funder, Erik Daa; Jensen, Anne Bjornskov; Torring, Thomas; Kodal, Anne Louise Bank; Azcargorta, Ane Rebolledo; Gothelf, Kurt Vesterager
Journal of Organic Chemistry, 2012 , vol. 77, # 7 p. 3134 - 3142
反应条件
1: N-bromosuccinmide; dibenzoyl peroxide / tetrachloromethane / 18 h / 70 °C
2: dimethyl sulfoxide / 0.33 h / 50 - 90 °C
View Scheme
参考文献
Kukosha, Tatyana; Trufilkina, Nadezhda; Katkevics, Martins
Synlett, 2011 , # 17 p. 2525 - 2528
反应条件
toluene; trichlorophosphate
参考文献
Stevens
Journal of the Chemical Society, 1935 , p. 663,667
反应条件
2: ammonia; methanol / 130 °C
3: phosphoryl chloride; toluene
View Scheme
参考文献
Stevens
Journal of the Chemical Society, 1935 , p. 663,667
反应条件
1: ammonia; methanol / 130 °C
2: phosphoryl chloride; toluene
View Scheme
参考文献
Stevens
Journal of the Chemical Society, 1935 , p. 663,667
反应条件
2: acetic acid anhydride
View Scheme
参考文献
Stevens
Journal of the Chemical Society, 1935 , p. 663,667
