4-甲氧基-2.3.6-三甲基苯甲醛合成路线 （共 16 条）
反应条件
trichlorophosphate T=70°C; 24 h;
参考文献
Makin, S. M.; Mikerin, I. E.; Dobretsova, E. K.; Shavrygina, O. A.
Russian Journal of Organic Chemistry, 1993 , vol. 29, # 4 p. 572 - 575
Zhurnal Organicheskoi Khimii, 1993 , vol. 29, # 4 p. 682 - 686
反应条件
potassium hydroxide; sodium acetate; trichlorophosphate in N-methyl-acetamide; ethanol; water; benzene
反应条件
tin(IV) chloride Formylation;
参考文献
Lewin; Black; Bos; Goehring; Nair; Whiting; Bouquin; Tetrault; Carroll
Pharmaceutical Research, 1995 , vol. 12, # 7 p. 983 - 992
反应条件
1.1: 90 percent / NaH / dimethylsulfoxide; various solvent(s) / 12 h / 30 - 40 °C 2.1: POCl3 / 1 h 2.2: 63 percent / 24.5 h / 0 - 20 °C View Scheme
参考文献
Helvetica Chimica Acta, , vol. 85, # 9 p. 2926 - 2929
反应条件
1: 90.7 percent / conc. H2SO4, 98percent aq. HNO3 / CHCl3 / 2 h / 0 °C 2: 75.5 percent / NaOH, H2 / Raney Ni / ethanol / 114000 Torr 3: 1.) 25percent aq, H2SO4, aq. NaNO2, 2.) 20percent aq. H2SO4 / 1.) 0 deg C, 1 h, 2.) reflux, 2 h 4: 98 percent / NaH / dimethylsulfoxide / 10 h 5: 72 percent / phosphorus oxychloride / 24 h / 70 °C View Scheme
参考文献
Russian Journal of Organic Chemistry, , vol. 29, # 4 p. 572 - 575
Zhurnal Organicheskoi Khimii, , vol. 29, # 4 p. 682 - 686
反应条件
1: 75.5 percent / NaOH, H2 / Raney Ni / ethanol / 114000 Torr 2: 1.) 25percent aq, H2SO4, aq. NaNO2, 2.) 20percent aq. H2SO4 / 1.) 0 deg C, 1 h, 2.) reflux, 2 h 3: 98 percent / NaH / dimethylsulfoxide / 10 h 4: 72 percent / phosphorus oxychloride / 24 h / 70 °C View Scheme
参考文献
Russian Journal of Organic Chemistry, , vol. 29, # 4 p. 572 - 575
Zhurnal Organicheskoi Khimii, , vol. 29, # 4 p. 682 - 686
反应条件
1: 1.) 25percent aq, H2SO4, aq. NaNO2, 2.) 20percent aq. H2SO4 / 1.) 0 deg C, 1 h, 2.) reflux, 2 h 2: 98 percent / NaH / dimethylsulfoxide / 10 h 3: 72 percent / phosphorus oxychloride / 24 h / 70 °C View Scheme
参考文献
Russian Journal of Organic Chemistry, , vol. 29, # 4 p. 572 - 575
Zhurnal Organicheskoi Khimii, , vol. 29, # 4 p. 682 - 686
反应条件
lithium aluminium tetrahydride
参考文献
Bestmann; Ermann
1984 , vol. 1984, # 10 p. 1740 - 1745
参考文献
Lewin; Black; Bos; Goehring; Nair; Whiting; Bouquin; Tetrault; Carroll
Pharmaceutical Research, 1995 , vol. 12, # 7 p. 983 - 992
反应条件
1: Na<AlH2(OCH2CH2OMe)2> / benzene; diethyl ether 2: PBr3, Py / diethyl ether View Scheme
参考文献
Pawson; Chan; DeNoble; Han; Piermattie; Specian; Srisethnil; Trown; Bohoslawec; Machlin; Gabriel
Journal of Medicinal Chemistry, 1979 , vol. 22, # 9 p. 1059 - 1067
