反应条件
1.1: bromine / water / 2 h / 50 °C 2.1: diethylamine; trichlorophosphate / 5 h / Reflux 3.1: sodium hydride / N,N-dimethyl-formamide / 0 °C 3.2: 1 h / 0 °C 4.1: hydrogenchloride; water / 16 h / Reflux View Scheme
参考文献
Chekler, Eugene L. Piatnitski; Unwalla, Rayomond; Khan, Taukeer A.; Tangirala, Raghuram S.; Johnson, Mark; St. Andre, Michael; Anderson, James T.; Kenney, Thomas; Chiparri, Sue; McNally, Chris; Kilbourne, Edward; Thompson, Catherine; Nagpal, Sunil; Weber, Gregory; Schelling, Scott; Owens, Jane; Morris, Carl A.; Powell, Dennis; Verhoest, Patrick R.; Gilbert, Adam M.
Journal of Medicinal Chemistry, 2014 , vol. 57, # 6 p. 2462 - 2471