反应条件
1: 87 percent / PCl5, POCl3 / 6 h / 130 - 140 °C 2: 77 percent / N2H4*H2O / ethanol / 1.) 0 deg C, 0.75 h, 2.) 25 deg C, 3.5 h 3: tetrahydrofuran / 1.) 0 deg C, 1.5 h, 2.) 25 deg C, overnight 4: H2 / 5percent Pd/C / aq. ethanol / 2327.2 Torr 5: HCl / ethanol / 1.) 25 deg C, 5 h, 2.) reflux, 1.5 h 6: MnO2, 5 M NaOH / H2O / 0.83 h / pH 6 View Scheme
参考文献
Reich; Fabio; Lee; Kuck; Testa
Journal of Medicinal Chemistry, 1989 , vol. 32, # 11 p. 2474 - 2485
