5,5-二甲基-3-氧代己酸乙酯合成路线 （共 9 条）
参考文献
Freidmann; Hansel
Archiv der Pharmazie, 1983 , vol. 316, # 8 p. 726 - 727
参考文献
Freidmann; Hansel
Archiv der Pharmazie, 1983 , vol. 316, # 8 p. 726 - 727
反应条件
sodium ethanolate
unter Abdestillieren des freigesetzten Aethanols;
参考文献
Mallinckrodt Chem. Works
Patent: US2367632 , 1942 ;
Full Text Show Details
Mallinckrodt Chem. Works
Patent: US2407942 , 1941 ;
Full Text Show Details
Wallingford; Homeyer; Jones
Journal of the American Chemical Society, 1941 , vol. 63, p. 2252
参考文献
Trahanovsky, Walter S.; Huang, Yih-chuan Jason; Leung, Man-kit
Journal of Organic Chemistry, 1994 , vol. 59, # 9 p. 2594 - 2598
反应条件
tin(ll) chloride in dichloromethane
T=20°C;
参考文献
Sund, Christian; Belda, Oscar; Borkakoti, Neera; Lindberg, Jimmy; Derbyshire, Dean; Vrang, Lotta; Hamelink, Elizabeth; Hgren, Cathrine; Woestenenk, Esmeralda; Wikstroem, Kristina; Eneroth, Anders; Lindstroem, Erik; Kalayanov, Genadiy
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 21 p. 6721 - 6727,7
反应条件
1: 86 percent / SOCl2 / 20 h / 25 °C
2: 1.) 2,2-bipyridyl, n-BuLi / 1.) THF, hexane, from below -60 to -5 deg C, 2.) -70 deg C, 45 min
View Scheme
参考文献
House, Herbert O.; Outcalt, Russell J.; Cliffton, Michael D.
Journal of Organic Chemistry, 1982 , vol. 47, # 12 p. 2413 - 2419
反应条件
[2,2']bipyridinyl; n-butyllithium
1.) THF, hexane, from below -60 to -5 deg C, 2.) -70 deg C, 45 min; Yield given. Multistep reaction;
参考文献
House, Herbert O.; Outcalt, Russell J.; Cliffton, Michael D.
Journal of Organic Chemistry, 1982 , vol. 47, # 12 p. 2413 - 2419
反应条件
1: hydrazine hydrate / ethanol / 70 °C
2: triethylamine / tetrahydrofuran / 0 - 20 °C
3: palladium hydroxide on carbon; hydrogen / ethyl acetate; acetic acid / 760.05 Torr
View Scheme
参考文献
Sund, Christian; Belda, Oscar; Borkakoti, Neera; Lindberg, Jimmy; Derbyshire, Dean; Vrang, Lotta; Hamelink, Elizabeth; Hgren, Cathrine; Woestenenk, Esmeralda; Wikstroem, Kristina; Eneroth, Anders; Lindstroem, Erik; Kalayanov, Genadiy
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 21 p. 6721 - 6727,7
反应条件
bromine in water
T=0°C; 1 h;
参考文献
Sanofi-Synthelabo
Patent: US2005/182104 A1, 2005 ;
Location in patent: Page/Page column 7 ;
