4,4-二甲氧基-2-丁酮合成路线 （共 125 条）
反应条件
1: 2-Nitrothiophene With hydrogenchloride; tin in water T=20 - 30°C; 2: With zinc(II) chloride in ethanol; water T=75°C; 1 h; 3: 4,4-dimethoxy-butan-2-one With sodium hydroxide more than 3 stages;
参考文献
Abbott Laboratories
Patent: US2008/153860 A1, 2008 ;
Location in patent: Page/Page column 24-25 ;
参考文献
Cazin, J.; Dupas, G.; Bourguignon, J.; Queguiner, G.
Tetrahedron Letters, 1986 , vol. 27, # 21 p. 2375 - 2378
反应条件
in methanol T=20°C; 12 h; Inert atmosphere;
参考文献
Petronijevic, Filip R.; Wipf, Peter
Journal of the American Chemical Society, 2011 , vol. 133, # 20 p. 7704 - 7707
反应条件
ammonium acetate; acetic acid
参考文献
Angewandte Chemie, , vol. 67, p. 395,398
参考文献
Degussa AG
Patent: EP1457489 A1, 2004 ;
Location in patent: Page 3 ;
参考文献
Bredereck
Organic Syntheses, 1973 , vol. Coll. Vol. V, p. 794
参考文献
Bayer Aktiengesellschaft
Patent: US4645528 A1, 1987 ;
反应条件
1: With piperidinium acetate in toluene T=20°C; 16.3 h; 2: With sulfuric acid T=50°C; 2 h;
参考文献
LG Life Sciences Ltd.
Patent: US2010/16376 A1, 2010 ;
Location in patent: Page/Page column 7 ;
US 20100016376 A1
反应条件
sodium acetate in ethanol Heating;
参考文献
Zimmer; Amer; Baldwin
Pharmazie, 1982 , vol. 37, # 6 p. 451 - 452
反应条件
AlCl3, aluminium chloride in ethanol; acetic acid T=60°C; 15 h;
参考文献
Maeda, Sayuki; Obora, Yasushi; Ishii, Yasutaka
European Journal of Organic Chemistry, 2009 , # 24 p. 4067 - 4072
