3-甲基-2-硝基苯甲酸合成路线 （共 57 条）
反应条件
1: 99 percent / H2 / Pd/C / ethanol / 20 °C / 25857.4 Torr
2: 87 percent / 2 h / Heating
3: 99 percent / HNO3; sulfuric acid / 8 h / 0 - 5 °C
View Scheme
参考文献
Montoya-Pelaez, Pedro J.; Uh, Yoon-Seo; Lata, Christopher; Thompson, Matthew P.; Lemieux, Robert P.; Crudden, Cathleen M.
Journal of Organic Chemistry, 2006 , vol. 71, # 16 p. 5921 - 5929
反应条件
phosphorus pentachloride
参考文献
Phillips; Hartman
Journal of Heterocyclic Chemistry, 1986 , vol. 23, # 3 p. 897 - 899
反应条件
1: SOCl2, DMF
2: 61 percent / NaBH4 / dimethylformamide; tetrahydrofuran / 3 h / Ambient temperature
3: 89 percent / pyridinium chlorochromate / CH2Cl2 / 2 h
View Scheme
参考文献
Phillips; Hartman
Journal of Heterocyclic Chemistry, 1986 , vol. 23, # 3 p. 897 - 899
反应条件
ammonia; triethylamine in tetrahydrofuran; chloroformic acid ethyl ester
参考文献
ICI Americas Inc.
Patent: US4975435 A1, 1990 ;
反应条件
ammonia in N-methyl-acetamide; dichloromethane; water
参考文献
E. R. Squibb and Sons, Inc.
Patent: US5466704 A1, 1995 ;
US 5466704 A
反应条件
1: permanganate
2: tin (II)-chloride; glacial acetic acid; hydrochloric acid
3: Diazotization.man erhitzt die Diazoniumsalz-Loesung mit Jod-Kaliumjodid-Loesung auf 80grad
4: alcoholic NaOH-solution
View Scheme
参考文献
James; Kenner; Stubbings
Journal of the Chemical Society, 1920 , vol. 117, p. 775
反应条件
1: dimethylsulfide borane complex / tetrahydrofuran / 3 h / 80 °C / |Inert atmosphere
2: phosphorus tribromide / diethyl ether / 3 h / |Inert atmosphere
View Scheme
参考文献
Kong, Chen; Jana, Navendu; Driver, Tom G.
Organic Letters, 2013 , vol. 15, # 4 p. 824 - 827
