1,4-二苯基-3,3-二甲基氮杂环丁烷-2-酮合成路线 （共 28 条）
反应条件
Li-naphthalenide in tetrahydrofuran
1.) -50 deg C, 30 min, 2.) r.temp., 24 h;
参考文献
Agawa, Toshio; Ishida, Masaru; Ohshiro, Yoshiki
Synthesis, 1980 , # 11 p. 933 - 935
反应条件
titanium tetrachloride in dichloromethane
Ambient temperature;
参考文献
Dubois, Jacqes-Emile; Axiotis, Georges
Tetrahedron Letters, 1984 , vol. 25, # 20 p. 2143 - 2146
参考文献
Holley; Holley
Journal of the American Chemical Society, 1951 , vol. 73, p. 3172
反应条件
lithium methanolate in N,N-dimethyl-formamide
T=20°C; Mannich-type reaction; 3 h;
参考文献
Takahashi, Eiki; Fujisawa, Hidehiko; Yanai, Toshiharu; Mukaiyama, Teruaki
Chemistry Letters, 2005 , vol. 34, # 2 p. 216 - 217
反应条件
1: ethyl acetate
2: Raney nickel; ethanol
View Scheme
参考文献
Holley; Holley
Journal of the American Chemical Society, 1951 , vol. 73, p. 3172
反应条件
P[2,4,6-(OMe)3C6H2]3 in N,N-dimethyl-formamide
T=20°C; 1 h;
参考文献
Matsukawa, Satoru; Obu, Kayoko
Chemistry Letters, 2004 , vol. 33, # 12 p. 1626 - 1627
反应条件
potassium phtalimide in N,N-dimethyl-formamide
T=-45°C; Mannich-type reaction; 24 h;
参考文献
Takahashi, Eiki; Fujisawa, Hidehiko; Yanai, Toshiharu; Mukaiyama, Teruaki
Chemistry Letters, 2005 , vol. 34, # 2 p. 216 - 217
反应条件
1.1: toluene / |Dean-Stark; |Reflux
2.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -78 °C / |Inert atmosphere
2.2: -78 - 20 °C / |Inert atmosphere
3.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / |Inert atmosphere; |Cooling
3.2: 1 h / |Inert atmosphere
View Scheme
参考文献
Geherty, Maryll; Melnyk, James; Chomsky, Keith; Hunt, David A.
Tetrahedron Letters, 2013 , vol. 54, # 36 p. 4934 - 4936
反应条件
2: 89 percent / aq. KOH / CH2Cl2
View Scheme
参考文献
Marchand-Brynaert, Jacqueline; Moya-Portuguez, Manuel; Huber, Isabelle; Ghosez, Leon
Journal of the Chemical Society, Chemical Communications, 1983 , # 15 p. 818 - 819
反应条件
1.1: toluene / |Dean-Stark; |Reflux
2.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -78 °C / |Inert atmosphere
2.2: -78 - 20 °C / |Inert atmosphere
3.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / |Inert atmosphere; |Cooling
3.2: 1 h / |Inert atmosphere
View Scheme
参考文献
Geherty, Maryll; Melnyk, James; Chomsky, Keith; Hunt, David A.
Tetrahedron Letters, 2013 , vol. 54, # 36 p. 4934 - 4936
