1,4-二苯基-3,3-二甲基氮杂环丁烷-2-酮合成路线 （共 28 条）
反应条件
1.1: toluene / |Dean-Stark; |Reflux
2.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -78 °C / |Inert atmosphere
2.2: -78 - 20 °C / |Inert atmosphere
3.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / |Inert atmosphere; |Cooling
3.2: 1 h / |Inert atmosphere; |Cooling
View Scheme
参考文献
Geherty, Maryll; Melnyk, James; Chomsky, Keith; Hunt, David A.
Tetrahedron Letters, 2013 , vol. 54, # 36 p. 4934 - 4936
反应条件
1.1: toluene / |Dean-Stark; |Reflux
2.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -78 °C / |Inert atmosphere
2.2: -78 - 20 °C / |Inert atmosphere
3.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / |Inert atmosphere; |Cooling
3.2: 1 h / |Inert atmosphere
View Scheme
参考文献
Geherty, Maryll; Melnyk, James; Chomsky, Keith; Hunt, David A.
Tetrahedron Letters, 2013 , vol. 54, # 36 p. 4934 - 4936
反应条件
1.1: toluene / |Dean-Stark; |Reflux
2.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -78 °C / |Inert atmosphere
2.2: -78 - 20 °C / |Inert atmosphere
3.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / |Inert atmosphere; |Cooling
3.2: 1 h / |Inert atmosphere
View Scheme
参考文献
Geherty, Maryll; Melnyk, James; Chomsky, Keith; Hunt, David A.
Tetrahedron Letters, 2013 , vol. 54, # 36 p. 4934 - 4936
反应条件
1.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -78 °C / |Inert atmosphere
1.2: -78 - 20 °C / |Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / |Inert atmosphere; |Cooling
2.2: 1 h / |Inert atmosphere
View Scheme
参考文献
Geherty, Maryll; Melnyk, James; Chomsky, Keith; Hunt, David A.
Tetrahedron Letters, 2013 , vol. 54, # 36 p. 4934 - 4936
反应条件
1.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -78 °C / |Inert atmosphere
1.2: -78 - 20 °C / |Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / |Inert atmosphere; |Cooling
2.2: 1 h / |Inert atmosphere; |Cooling
View Scheme
参考文献
Geherty, Maryll; Melnyk, James; Chomsky, Keith; Hunt, David A.
Tetrahedron Letters, 2013 , vol. 54, # 36 p. 4934 - 4936
反应条件
1.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -78 °C / |Inert atmosphere
1.2: -78 - 20 °C / |Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / |Inert atmosphere; |Cooling
2.2: 1 h / |Inert atmosphere
View Scheme
参考文献
Geherty, Maryll; Melnyk, James; Chomsky, Keith; Hunt, David A.
Tetrahedron Letters, 2013 , vol. 54, # 36 p. 4934 - 4936
反应条件
lithium diisopropyl amide
1)-78 deg C, THF, 15 min, 2)-78 deg C, 4-5 h, 3)3-8 h room temperature; Yield given. Multistep reaction;
参考文献
Gluchowski; Cooper; Bergbreiter; Newcomb
Journal of Organic Chemistry, 1980 , vol. 45, # 17 p. 3413 - 3416
参考文献
Staudinger; Klever
Chemische Berichte, 1907 , vol. 40, p. 1151
