3-氨基吡唑-4,5-二甲腈合成路线 （共 9 条）
参考文献
Sterling Winthrop Inc.
Patent: US5294612 A1, 1994 ;
参考文献
Korbukh,I.A. et al.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1979 , vol. 15, p. 1361 - 1366
Khimiya Geterotsiklicheskikh Soedinenii, 1979 , vol. 15, p. 1687 - 1692
反应条件
1: 51 percent / methanol / 8 h / Heating
2: 83 percent / 20percent aq. NH4OH / 5 h / Heating
View Scheme
参考文献
Bulychev, Yu. N.; Korbukh, I. A.; Preobrazhenskaya, M. N.; Chernyshov, A. I.; Esipov, S. E.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1984 , vol. 20, # 2 p. 215 - 221
Khimiya Geterotsiklicheskikh Soedinenii, 1984 , vol. 20, # 2 p. 259 - 264
反应条件
1: 3 h / 100 - 110 °C
2: 1) CH3ONa; 2) H2S / 1) MeOH; 2) reflux, 4 h
3: 89 percent / 1M aq. NaOH / H2O / 2 h / 20 °C
View Scheme
参考文献
Bulychev, Yu. N.; Korbukh, I. A.; Preobrazhenskaya, M. N.; Chernyshov, A. I.; Esipov, S. E.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1984 , vol. 20, # 2 p. 215 - 221
Khimiya Geterotsiklicheskikh Soedinenii, 1984 , vol. 20, # 2 p. 259 - 264
反应条件
1: 3 h / 100 - 110 °C
2: 1) CH3ONa; 2) H2S / 1) MeOH; 2) reflux, 4 h
View Scheme
参考文献
Bulychev, Yu. N.; Korbukh, I. A.; Preobrazhenskaya, M. N.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1984 , vol. 20, # 2 p. 210 - 215
Khimiya Geterotsiklicheskikh Soedinenii, 1984 , vol. 20, # 2 p. 253 - 258
参考文献
Bulychev, Yu.N.; Korbukh, I.A.; Preobrazhenskaya, M.N.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1982 , vol. 18, # 12 p. 1302 - 1305
Khimiya Geterotsiklicheskikh Soedinenii, 1982 , vol. 18, # 12 p. 1682 - 1685
反应条件
5 h; Heating; Title compound not separated from byproducts;
参考文献
Bulychev, Yu.N.; Korbukh, I.A.; Preobrazhenskaya, M.N.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1982 , vol. 18, # 12 p. 1302 - 1305
Khimiya Geterotsiklicheskikh Soedinenii, 1982 , vol. 18, # 12 p. 1682 - 1685
反应条件
1: 3 h / 100 - 110 °C
2: 1) CH3ONa; 2) H2S / 1) MeOH; 2) reflux, 4 h
3: 89 percent / 1M aq. NaOH / H2O / 2 h / 20 °C
4: 50 percent / H2S, Triethylamine / ethanol / 6 h / 20 °C
View Scheme
参考文献
Bulychev, Yu. N.; Korbukh, I. A.; Preobrazhenskaya, M. N.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1984 , vol. 20, # 2 p. 210 - 215
Khimiya Geterotsiklicheskikh Soedinenii, 1984 , vol. 20, # 2 p. 253 - 258
反应条件
1: 3 h / 100 - 110 °C
2: 1) CH3ONa; 2) H2S / 1) MeOH; 2) reflux, 4 h
3: 89 percent / 1M aq. NaOH / H2O / 2 h / 20 °C
4: 61 percent / Iodine / 0.75 h / 165 °C / 10 - 15 Torr
5: 53 percent / H2S, Triethylamine / ethanol / 1.5 h / 20 °C
6: 52 percent / gaseous NH3 / methanol / 8 h / 100 °C
View Scheme
参考文献
Bulychev, Yu. N.; Korbukh, I. A.; Preobrazhenskaya, M. N.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1984 , vol. 20, # 2 p. 210 - 215
Khimiya Geterotsiklicheskikh Soedinenii, 1984 , vol. 20, # 2 p. 253 - 258
