反应条件
1: Et3N / toluene / 3 h / Heating
2: pyridine
3: H2, CaCO3 / 10percent Pd/C / CHCl3 / 18 h / 40 °C / 1034.3 Torr
4: 1.) Et3N, 2.) Et3N, water / 1.) diethyl ether, RT, 5 h, 2.) diethyl ether, reflux, 2 h
5: CHCl3; propan-2-ol; dimethylformamide / 12 h / 50 °C
View Scheme
参考文献
Godfroid, Jean-Jacques; Broquet, Colette; Jouquey, Simone; Lebbar, Mariya; Heymans, Francoise; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 5 p. 792 - 797
