5,6-二氨基-1,3-二甲基尿苷水合物合成路线 （共 107 条）
反应条件
aluminum oxide microwave irradiation;
参考文献
Singh; Geetanjali
Russian Journal of Organic Chemistry, 2006 , vol. 42, # 1 p. 136 - 138
反应条件
pyridine 4 h; Ambient temperature;
参考文献
Jacobson, Kenneth A.; Shi, Dan; Gallo-Rodriguez, Carola; Manning, Malcolm; Mueller, Christa; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 18 p. 2639 - 2644
反应条件
in methanol; water 0.5 h; Ambient temperature;
参考文献
Mineo; Ogura; Nakagawa
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 9 p. 2835 - 2838
反应条件
beim anschliessenden Erwaermen des Reaktionsprodukts mit wss. NaOH;
参考文献
Pretorius, Judey; Malan, Sarel F.; Castagnoli Jr., Neal; Bergh, Jacobus J.; Petzer, Jacobus P.
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 18 p. 8676 - 8684
反应条件
beim anschliessenden Erwaermen des Reaktionsprodukts mit wss. NaOH;
参考文献
Hager; Kramer
Journal of the American Pharmaceutical Association (1912-1977), 1955 , vol. 44, p. 649,652
反应条件
1: 89 percent / ethanol / 1 h / Ambient temperature 2: 86 percent / 5percent NaHCO3 / H2O / 0.08 h / Heating 3: 75 percent / acetic anhydride / 24 h / Heating View Scheme
参考文献
Kang, Yonghan; Soyka, Rainer; Pfleiderer, Wolfgang
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 597 - 602
反应条件
1: 89 percent / ethanol / 1 h / Ambient temperature
2: 86 percent / 5percent NaHCO3 / H2O / 0.08 h / Heating
3: 94 percent / 5N aq. HCl, 37percent aq. formaldehyde / H2O / 0.5 h / Heating
4: 76 percent / 0.1 N NaOH, 1percent KMnO4 / H2O / 1.5 h / Ambient temperature
View Scheme
参考文献
Kang, Yonghan; Soyka, Rainer; Pfleiderer, Wolfgang
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 597 - 602
参考文献
Hager et al.
Journal of the American Pharmaceutical Association (1912-1977), 1954 , vol. 43, p. 152,154
参考文献
Hager; Kramer
Journal of the American Pharmaceutical Association (1912-1977), 1955 , vol. 44, p. 649,652
反应条件
1: 64 percent / 1 h / 120 °C
2: base / H2O
View Scheme
参考文献
Rybar, A.; Alfoeldi, J.; Smondrkova, I.
Monatshefte fuer Chemie, 1994 , vol. 125, # 5 p. 565 - 570
