5,6-二氨基-1,3-二甲基尿苷水合物合成路线 （共 107 条）
反应条件
1: 99 percent / 1.) 100 deg C, 4 h; 2.) 20 deg C, 20 h
2: 47 percent / 12N NaOH / H2O / 2 h / 100 °C
3: 75 percent / 48percent HBr, HBr (gas) / 20 h / Heating
4: 22 percent / methanol / 20 h / Heating
View Scheme
参考文献
Regnier, Gilbert L.; Guillonneau, Claude G.; Duhault, Jacques L.; Tisserand, Francoise P.; Saint-Romas, Guy; Holstorp, Sophie M.
European Journal of Medicinal Chemistry, 1987 , vol. 22, p. 243 - 250
反应条件
aluminum oxide
microwave irradiation;
参考文献
Singh; Geetanjali
Russian Journal of Organic Chemistry, 2006 , vol. 42, # 1 p. 136 - 138
参考文献
Shealy,Y.F. et al.
Journal of Organic Chemistry, 1962 , vol. 27, p. 2154 - 2160
参考文献
Traube,W.
Chemische Berichte, 1900 , vol. 33, p. 3047
Chem. Zentralbl., 1901 , vol. 72, # I p. 548
参考文献
Bayer and Co.
Patent: DE213711 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 9, p. 1010
反应条件
1: 95 percent / ethanol
2: 73 percent / 85 percent m-CPBA / acetonitrile / Ambient temperature
View Scheme
参考文献
De Araujo, Aline D.; Bacher, Edmond; Joachim Demnitz; Santos, Douglas A.
Heterocycles, 1999 , vol. 51, # 1 p. 29 - 36
参考文献
Speer; Raymond
Journal of the American Chemical Society, 1953 , vol. 75, p. 114
反应条件
triethylamine; chlorodiphenylphosphine oxide in ethyl acetate
T=20°C;
参考文献
Isobe, Yoshiaki; Tobe, Masanori; Inoue, Yoshifumi; Goto, Yuso; Obara, Fumihiro; Isobe, Masakazu; Hayashi, Hideya
Chemical and pharmaceutical bulletin, 2003 , vol. 51, # 3 p. 309 - 312
反应条件
in methanol; water
0.5 h; Ambient temperaturevar. aldehydes; Product distribution;
参考文献
Mineo; Ogura; Nakagawa
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 9 p. 2835 - 2838
反应条件
2: concentrated aqueous HCl
View Scheme
参考文献
Blicke; Schaaf
Journal of the American Chemical Society, 1956 , vol. 78, p. 5857,5860
