1: With trifluoroacetic acid in dichloromethane T=0°C; 4 h; Inert atmosphere; 2: With triethylamine in dichloromethane

sodium hydride

1: triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere 2: diisobutylaluminium hydride / tetrahydrofuran; toluene / 2 h / 20 °C / Inert atmosphere 3: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 20 °C / Inert atmosphere 4: trifluoroacetic acid / dichloromethane / 4 h / 0 °C / Inert atmosphere View Scheme

di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran T=20°C; Mitsunobu reaction; Inert atmosphere;

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 20 °C / Inert atmosphere 2: trifluoroacetic acid / dichloromethane / 4 h / 0 °C / Inert atmosphere View Scheme

1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 2 h / 20 °C / Inert atmosphere 2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 20 °C / Inert atmosphere 3: trifluoroacetic acid / dichloromethane / 4 h / 0 °C / Inert atmosphere View Scheme

trichlorophosphate

2: POCl3 View Scheme

1.1: borane-THF / tetrahydrofuran / 0.5 h / -78 - 0 °C / Inert atmosphere 2.1: lithium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl-formamide / 0.02 h / -78 °C / Inert atmosphere 2.2: 0.33 h / -78 - 20 °C / Inert atmosphere 3.1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C / Inert atmosphere 4.1: manganese(IV) oxide / dichloromethane / 1 h / 20 °C / Inert atmosphere View Scheme

1.1: lithium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl-formamide / 0.02 h / -78 °C / Inert atmosphere 1.2: 0.33 h / -78 - 20 °C / Inert atmosphere 2.1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C / Inert atmosphere 3.1: manganese(IV) oxide / dichloromethane / 1 h / 20 °C / Inert atmosphere View Scheme