2-乙酰氨基-4-苯基-丁酸合成路线 （共 10 条）
反应条件
1: CoCl2 / H2O / 72 h / 37 °C / aminoacylase (from Aspergillus oryzae); pH 7 2: SOCl2 View Scheme
参考文献
Hayashi, Kimiaki; Nunami, Ken-ichi; Kato, Jyoji; Yoneda, Naoto; Kubo, Masami; et al.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 2 p. 289 - 297
反应条件
sodium hydroxide; potassium phosphate buffer; beef kidney acetone; CoCl2 T=37°C; pH=7.5; 24 h; Enzymatic reaction;
参考文献
Tetrahedron Asymmetry, , vol. 15, # 8 p. 1285 - 1288
反应条件
CoCl2 in water T=37°C; 72 h; aminoacylase (from Aspergillus oryzae); pH 7;
参考文献
Youshko, Maxim I.; Van Langen, Luuk M.; Sheldon, Roger A.; Svedas, Vytas K.
Tetrahedron Asymmetry, 2004 , vol. 15, # 12 p. 1933 - 1936
反应条件
1: CoCl2 / H2O / 72 h / 37 °C / aminoacylase (from Aspergillus oryzae); pH 7 2: SOCl2 3: 43.6 percent / K2CO3 / dimethylsulfoxide / 30 h / Ambient temperature 4: ethyl acetate; diisopropyl ether 5: 96 percent / H2 / Pd / ethanol / 3 h / 760 Torr / Ambient temperature View Scheme
参考文献
Hayashi, Kimiaki; Nunami, Ken-ichi; Kato, Jyoji; Yoneda, Naoto; Kubo, Masami; et al.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 2 p. 289 - 297
反应条件
1: CoCl2 / H2O / 72 h / 37 °C / aminoacylase (from Aspergillus oryzae); pH 7 2: benzene / 6 h / Heating 3: 40.8 percent / K2CO3 / dimethylsulfoxide / 30 h / Ambient temperature 4: ethyl acetate; diisopropyl ether 5: 94 percent / 15percent HCl/dioxane / Ambient temperature 6: DCC / tetrahydrofuran / Ambient temperature 7: 1) tBuOK / 1) THF, -50 deg C, 20 min, 2) THF, -30 deg C, 20 min 8: ethyl acetate; diisopropyl ether / 3 h / Ambient temperature 9: H2 / Pd / methanol / 2 h / 760 Torr / Ambient temperature View Scheme
参考文献
Hayashi, Kimiaki; Nunami, Ken-ichi; Kato, Jyoji; Yoneda, Naoto; Kubo, Masami; et al.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 2 p. 289 - 297
反应条件
1: CoCl2 / H2O / 72 h / 37 °C / aminoacylase (from Aspergillus oryzae); pH 7 2: SOCl2 3: 43.6 percent / K2CO3 / dimethylsulfoxide / 30 h / Ambient temperature 4: ethyl acetate; diisopropyl ether 5: 96 percent / H2 / Pd / ethanol / 3 h / 760 Torr / Ambient temperature 6: DCC / tetrahydrofuran / Ambient temperature 7: 1) tBuOK / 1) THF, -50 deg C, 20 min, 2) THF, -30 deg C, 20 min 8: ethyl acetate; diisopropyl ether / 3 h / Ambient temperature 9: 1) K2CO3, 2) 15percent HCl/dioxane / 1) H2O, 2) rt, overnight View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 32, # 2 p. 289 - 297
反应条件
hydrogenchloride Heating;
参考文献
Kubota; Nunami; Hayashi; Hashimoto; Ogiku; Matsuoka; Ishida
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 6 p. 1619 - 1622
反应条件
sodium hydroxide; potassium phosphate buffer; beef kidney acetone; CoCl2 T=37°C; pH=7.5; 24 h; Enzymatic reaction;
参考文献
Tetrahedron Asymmetry, , vol. 15, # 8 p. 1285 - 1288
反应条件
1: CoCl2 / H2O / 72 h / 37 °C / aminoacylase (from Aspergillus oryzae); pH 7
2: benzene / 6 h / Heating
3: 40.8 percent / K2CO3 / dimethylsulfoxide / 30 h / Ambient temperature
4: ethyl acetate; diisopropyl ether
5: 94 percent / 15percent HCl/dioxane / Ambient temperature
6: DCC / tetrahydrofuran / Ambient temperature
7: 1) tBuOK / 1) THF, -50 deg C, 20 min, 2) THF, -30 deg C, 20 min
View Scheme
参考文献
Hayashi, Kimiaki; Nunami, Ken-ichi; Kato, Jyoji; Yoneda, Naoto; Kubo, Masami; et al.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 2 p. 289 - 297
反应条件
sodium hydroxide; potassium phosphate buffer; beef kidney acetone; CoCl2
T=37°C; pH=7.5; 24 h; Enzymatic reaction;
参考文献
Regla, Ignacio; Luna, Hector; Perez, Herminia I.; Demare, Patricia; Bustos-Jaimes, Ismael; Zaldivar, Victor; Calcagno, Mario L.
Tetrahedron Asymmetry, 2004 , vol. 15, # 8 p. 1285 - 1288
