2-乙酰氨基-2-戊基-丙二酸二乙酯合成路线 （共 9 条）
参考文献
Van Hest, Jan C. M.; Kiick, Kristi L.; Tirrell, David A.
Journal of the American Chemical Society, 2000 , vol. 122, # 7 p. 1282 - 1288
参考文献
Albertson
Journal of the American Chemical Society, 1946 , vol. 68, p. 452
参考文献
Albertson
Journal of the American Chemical Society, 1946 , vol. 68, p. 452
反应条件
1: diethyl 2-acetylaminomalonate With potassium tert-butylate in tetrahydrofuran
T=60°C; Metallation; 2 h;
2: p-toluenesulfonic-acid-2-propylethylester in tetrahydrofuran
Alkylation; 48 h; Heating; Further stages.;
参考文献
Van Hest, Jan C. M.; Kiick, Kristi L.; Tirrell, David A.
Journal of the American Chemical Society, 2000 , vol. 122, # 7 p. 1282 - 1288
反应条件
1.1: pyridine / 3 h
2.1: t-BuOK / tetrahydrofuran / 2 h / 60 °C
2.2: tetrahydrofuran / 48 h / Heating
View Scheme
参考文献
Van Hest, Jan C. M.; Kiick, Kristi L.; Tirrell, David A.
Journal of the American Chemical Society, 2000 , vol. 122, # 7 p. 1282 - 1288
参考文献
Albertson
Journal of the American Chemical Society, 1946 , vol. 68, p. 452
反应条件
(i) NaOEt, KI, EtOH, (ii) /BRN= 1730981/; Multistep reaction;
参考文献
Andrako,J. et al.
Journal of Pharmaceutical Sciences, 1961 , vol. 50, p. 337 - 340
参考文献
Kiick, Kristi L.; Tirrell, David A.
Tetrahedron, 2000 , vol. 56, # 48 p. 9487 - 9493
参考文献
Andrako,J. et al.
Journal of Pharmaceutical Sciences, 1961 , vol. 50, p. 337 - 340
