4-乙氧羰基-3,5-二甲基吡咯-2-羧酸合成路线 （共 15 条）
反应条件
lithium aluminium tetrahydride; diethyl ether
参考文献
Treibs; Derra-Scherer
Justus Liebigs Annalen der Chemie, 1954 , vol. 589, p. 188,194
反应条件
1: aqueous methanol. NaOH; aqueous H2O2; aqueous HCl; KI
View Scheme
参考文献
Treibs; Kolm
Justus Liebigs Annalen der Chemie, 1958 , vol. 614, p. 176,195
反应条件
1: aqueous methanol. NaOH; aqueous H2O2; aqueous HCl; KI
2: acetic acid; bromine; concentrated aqueous HCl
View Scheme
参考文献
Treibs; Kolm
Justus Liebigs Annalen der Chemie, 1958 , vol. 614, p. 176,195
反应条件
iodine; potassium iodide in dichloromethane; water
2 h; Reflux;
参考文献
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co. Ltd.
Patent: EP2236500 A1, 2010 ;
Location in patent: Page/Page column 23 ;
反应条件
1: aqueous methanol. NaOH; aqueous H2O2; aqueous HCl; KI
2: aqueous Na2S2O3; aqueous HCl; ethanol
View Scheme
参考文献
Treibs; Kolm
Justus Liebigs Annalen der Chemie, 1958 , vol. 614, p. 176,195
