2-碘-4-甲氧基苯甲酸合成路线 （共 18 条）
反应条件
(i) aq. H2SO4, NaNO2, (ii) KI; Multistep reaction;
参考文献
Koizumi,J. et al.
Chemical and Pharmaceutical Bulletin, 1964 , vol. 12, # 6 p. 696 - 705
反应条件
potassium permanganate; tetrabutylammomium bromide in dichloromethane
T=20°C; 24 h;
参考文献
Liang, Pi-Hui; Hsin, Ling-Wei; Pong, Sung-Ling; Hsu, Chia-Huei; Cheng, Chen-Yu
Journal of the Chinese Chemical Society, 2003 , vol. 50, # 3 A p. 449 - 456
反应条件
hydrogenchloride; potassium iodide; sodium nitrite in water; toluene
参考文献
Sterling Winthrop Inc.
Patent: US5614530 A1, 1997 ;
反应条件
N,N,N',N,-tetramethylethylenediamine; iodine; sec.-butyllithium in tetrahydrofuran
T=-78 - 20°C;
参考文献
Nguyen, Thi-Huu; Chau, Nguyet Trang Thanh; Castanet, Anne-Sophie; Nguyen, Kim Phi Phung; Mortier, Jacques
Journal of Organic Chemistry, 2007 , vol. 72, # 9 p. 3419 - 3429
反应条件
1: H2 / Pd-C
2: (i) aq. H2SO4, NaNO2, (ii) KI
View Scheme
参考文献
Koizumi,J. et al.
Chemical and Pharmaceutical Bulletin, 1964 , vol. 12, # 6 p. 696 - 705
反应条件
1.1: t-BuLi / tetrahydrofuran; pentane / 0.5 h / -78 °C
1.2: I2 / tetrahydrofuran; pentane / 2 h / -78 °C
2.1: 32.6 g / aq. HCl / methanol / 0.5 h
3.1: 99 percent / KMnO4; (n-Bu)4NBr / CH2Cl2 / 24 h / 20 °C
View Scheme
参考文献
Liang, Pi-Hui; Hsin, Ling-Wei; Pong, Sung-Ling; Hsu, Chia-Huei; Cheng, Chen-Yu
Journal of the Chinese Chemical Society, 2003 , vol. 50, # 3 A p. 449 - 456
反应条件
1.1: p-TsOH / CH2Cl2 / 24 h / 20 °C
2.1: t-BuLi / tetrahydrofuran; pentane / 0.5 h / -78 °C
2.2: I2 / tetrahydrofuran; pentane / 2 h / -78 °C
3.1: 32.6 g / aq. HCl / methanol / 0.5 h
4.1: 99 percent / KMnO4; (n-Bu)4NBr / CH2Cl2 / 24 h / 20 °C
View Scheme
参考文献
Liang, Pi-Hui; Hsin, Ling-Wei; Pong, Sung-Ling; Hsu, Chia-Huei; Cheng, Chen-Yu
Journal of the Chinese Chemical Society, 2003 , vol. 50, # 3 A p. 449 - 456
反应条件
1: n-BuLi, I2 / 0 °C
2: 6 N HCl / Heating
View Scheme
参考文献
Berman, Ellen M.; Showalter, H. D. Hollis
Journal of Organic Chemistry, 1989 , vol. 54, # 23 p. 5642 - 5644
反应条件
1: Ca(OH)2, Na2CO3, aq. NaOH
2: Ag2O, aq. NaOH
3: aq. NaOH
View Scheme
参考文献
Kobayashi,S. et al.
Chemical and Pharmaceutical Bulletin, 1963 , vol. 11, # 1 p. 123 - 126
反应条件
1: Ag2O, aq. NaOH
2: aq. NaOH
View Scheme
参考文献
Kobayashi,S. et al.
Chemical and Pharmaceutical Bulletin, 1963 , vol. 11, # 1 p. 123 - 126
