1: acetoacetic acid n-butyl ester With ammonia in methanol
T=20°C;
2: p-benozquinone With acetic acid
T=20°C; Nenitzescu reaction; Further stages.;
参考文献
Boehme, Thomas M.; Augelli-Szafran, Corinne E.; Hallak, Hussein; Pugsley, Thomas; Serpa, Kevin; Schwarz, Roy D.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 14 p. 3094 - 3102
