反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere 2.1: sodium hydroxide / methanol / 0.5 h / Reflux 3.1: triethylamine; p-toluenesulfonyl chloride / benzene / Inert atmosphere; Reflux 4.1: bis(dibenzylideneacetone)-palladium(0); Pd0(tris(tert-butyl)phosphine)2 / toluene / 2 h / 100 °C / Inert atmosphere 5.1: hydrogenchloride; water / toluene; diethyl ether 5.2: pH 10 View Scheme
参考文献
MAPI PHARMA HOLDINGS (CYPRUS) LIMITED; MAROM, Ehud; MIZHIRITSKII, Michael; RUBNOV, Shai
Patent: WO2011/99010 A1, 2011 ;