5-硝基-2-甲氧基吡啶合成路线 （共 48 条）
反应条件
N,N-dimethyl-formamide; trichlorophosphate T=85°C; 8 h;
参考文献
Lai, Long-Li; Lin, Pen-Yuan; Wang, Jy-Shih; Hwu, Jih Ru; Shiao, Min-Jen; Tsay, Shwu-Chen
Journal of Chemical Research - Part S, 1996 , # 4 p. 194 - 195
反应条件
potassium permanganate T=-7°C; 0.5 h;
参考文献
Szpakiewicz, Barbara; Wozniak, Marian
Advanced Synthesis and Catalysis, 1999 , vol. 341, # 1 p. 75 - 78
反应条件
potassium fluoride; polymethylhydrosiloxane; palladium diacetate in tetrahydrofuran T=20°C; 0.5 h;
参考文献
Rahaim Jr., Ronald J.; Maleczka Jr., Robert E.
Synthesis, 2006 , # 19 p. 3316 - 3340
反应条件
ammonium chloride; potassium tert-butylate in dimethyl sulfoxide
参考文献
Sumitomo Chemical Company, Limited
Patent: US5648496 A1, 1997 ;
反应条件
methoxylamine hydrochloride; potassium tert-butylate; zinc(II) chloride in dimethyl sulfoxide Ambient temperature;
参考文献
Seko, Shinzo; Miyake, Kunihito
Chemical Communications, 1998 , # 15 p. 1519 - 1520
反应条件
ethanol; hydrazine hydrate
参考文献
Bollettino Scientifico della Facolta di Chimica Industriale di Bologna, , vol. 5, p. 32
反应条件
1: 97 percent / iron, calcium chloride / aq. ethanol / 2 h / Heating 2: Br2 / acetic acid / 0 - 5 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 30, # 1 p. 302 - 318
反应条件
1: 83 percent / potassium t-butoxide / tetrahydrofuran / 3 h / -15 °C 2: 81 percent / hydrogen / 10 percent palladium on charcoal / ethanol / 5 h / 2327.17 Torr / Ambient temperature 3: 32 percent / 33 percent acetic acid / H2O / 4 h / Heating View Scheme
参考文献
Mazeas, Daniel; Guillaumet, Gerald; Viaud, Marie-Claude
Heterocycles, 1999 , vol. 50, # 2 p. 1065 - 1080
反应条件
1: 94 percent / potassium tert-butoxide / tetrahydrofuran / 3.5 h / -10 °C 2: 71 percent / hydrogen / palladium on charcoal / ethanol / 5 h / 20 °C / 2327.17 Torr View Scheme
参考文献
Makosza, Mieczyslaw; Danikiewicz, Witold; Wojciechowski, Krzysztof
Liebigs Annalen der Chemie, 1988 , p. 203 - 208
反应条件
1: 94 percent / potassium tert-butoxide / tetrahydrofuran / 3.5 h / -10 °C
2: 71 percent / hydrogen / palladium on charcoal / ethanol / 5 h / 20 °C / 2327.17 Torr
3: 99 percent / sodium hydroxide / benzyltriethylammonium chloride / CH2Cl2 / 2.25 h / 0 - 20 °C
View Scheme
参考文献
Larraya, Carlos; Guillard, Jerome; Renard, Pierre; Audinot, Valerie; Boutin, Jean A.; Delagrange, Philippe; Bennejean, Caroline; Viaud-Massuard, Marie-Claude
European Journal of Medicinal Chemistry, 2004 , vol. 39, # 6 p. 515 - 526
