1-叔丁氧羰基哌啶-4-羧酸二甲胺合成路线 （共 5 条）
反应条件
1: With sodium tetrahydroborate in tetrahydrofuran T=0°C; 0.5 h; 2: With iodine in tetrahydrofuran 18 h; Heating / reflux; 3: With sodium hydroxide in water
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GmbH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2008/71646 A1, 2008 ;
Location in patent: Page/Page column 80 ;
WO 2008/071646 A1
反应条件
1: With hydrogenchloride in 1,4-dioxane; methanol T=0 - 20°C; 2: With ammonia in methanol
参考文献
CANCER RESEARCH TECHNOLOGY LIMITED; McDONALD, Edward; BLAGG, Julian; PICHOWICZ, Mark; CRUMPLER, Simon Ross
Patent: WO2010/41054 A1, 2010 ;
Location in patent: Page/Page column 32 ;
反应条件
1: 1-(t-butoxycarbonyl)-4-(carboxy)piperidine With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine in tetrahydrofuran
T=20°C; 1 h;
2: methylamine With triethylamine in tetrahydrofuran
48 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GmbH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2008/71646 A1, 2008 ;
Location in patent: Page/Page column 80 ;
WO 2008/071646 A1
反应条件
1: 1-(t-butoxycarbonyl)-4-(carboxy)piperidine With triethylamine; isobutyl chloroformate in tetrahydrofuran
T=0°C; 0.5 h;
2: methylamine in tetrahydrofuran
T=20°C;
参考文献
ARENA PHARMACEUTICALS, INC.
Patent: WO2005/7658 A2, 2005 ;
Location in patent: Page 230 ;
WO 2005/007658 A2
反应条件
1: 1-(t-butoxycarbonyl)-4-(carboxy)piperidine With N-ethyl-N,N-diisopropylamine; HATU in N,N-dimethyl-formamide
0.0833333 h;
2: N-methylamine hydrochloride in N,N-dimethyl-formamide
16 h;
参考文献
CANCER RESEARCH TECHNOLOGY LIMITED; McDONALD, Edward; BLAGG, Julian; PICHOWICZ, Mark; CRUMPLER, Simon Ross
Patent: WO2010/41054 A1, 2010 ;
Location in patent: Page/Page column 30 ;
