4,6-二甲基-2-(三氟甲基)嘧啶-5-羧酸合成路线 （共 6 条）
反应条件
1: With potassium hydroxide in ethanol; water
T=20 - 40°C;
2: With hydrogenchloride in water
参考文献
Lemoine, Remy C.; Petersen, Ann C.; Setti, Lina; Wanner, Jutta; Jekle, Andreas; Heilek, Gabrielle; deRosier, Andre; Ji, Changhua; Berry, Pamela; Rotstein, David
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 2 p. 704 - 708
反应条件
sodium hydroxide in ethanol
参考文献
Palani, Anandan; Shapiro, Sherry; Clader, John W.; Greenlee, William J.; Vice, Susan; McCombie, Stuart; Cox, Kathleen; Strizki, Julie; Baroudy, Bahige M.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 4 p. 709 - 712
反应条件
1: CsCO3 / acetonitrile
2: NaOEt / ethanol / Heating
3: acidic solution
View Scheme
参考文献
McCombie, Stuart W.; Tagat, Jayaram R.; Vice, Susan F.; Lin, Sue-Ing; Steensma, Ruo; Palani, Anandan; Neustadt, Bernard R.; Baroudy, Bahige M.; Strizki, Julie M.; Endres, Michael; Cox, Kathleen; Dan, Niya; Chou, Chuan-Chu
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 3 p. 567 - 571
反应条件
1.1: Cs2CO3 / acetonitrile
1.2: 58 percent / acetonitrile
2.1: NaOEt / 80 °C
3.1: 100 percent / NaOH / ethanol
View Scheme
参考文献
Palani, Anandan; Shapiro, Sherry; Clader, John W.; Greenlee, William J.; Vice, Susan; McCombie, Stuart; Cox, Kathleen; Strizki, Julie; Baroudy, Bahige M.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 4 p. 709 - 712
反应条件
1: NaOEt / ethanol / Heating
2: acidic solution
View Scheme
参考文献
McCombie, Stuart W.; Tagat, Jayaram R.; Vice, Susan F.; Lin, Sue-Ing; Steensma, Ruo; Palani, Anandan; Neustadt, Bernard R.; Baroudy, Bahige M.; Strizki, Julie M.; Endres, Michael; Cox, Kathleen; Dan, Niya; Chou, Chuan-Chu
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 3 p. 567 - 571
参考文献
McCombie, Stuart W.; Tagat, Jayaram R.; Vice, Susan F.; Lin, Sue-Ing; Steensma, Ruo; Palani, Anandan; Neustadt, Bernard R.; Baroudy, Bahige M.; Strizki, Julie M.; Endres, Michael; Cox, Kathleen; Dan, Niya; Chou, Chuan-Chu
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 3 p. 567 - 571
