2-羟基-4-(苯基甲氧基)-苯甲酸合成路线 （共 8 条）
反应条件
1: 2,4-dihydroxy-benzoic acid With sodium hydride in N,N-dimethyl-formamide; mineral oil
T=20°C; 1 h;
2: benzyl bromide in N,N-dimethyl-formamide; mineral oil
T=20°C; 7 h;
3: With hydrogenchloride in water; N,N-dimethyl-formamide; mineral oil
pH=1 - 3; regioselective reaction;
参考文献
Fan, Xing; Zhang, Feng-Hua; Al-Safi, Rasha I.; Zeng, Li-Fan; Shabaik, Yumna; Debnath, Bikash; Sanchez, Tino W.; Odde, Srinivas; Neamati, Nouri; Long, Ya-Qiu
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 16 p. 4935 - 4952
反应条件
piperazine in N,N-dimethyl acetamide
T=150°C; Substitution; 0.2 h;
参考文献
Nishioka, Hiroyasu; Nagasawa, Masaaki; Yoshida, Kiyoshi
Synthesis, 2000 , # 2 p. 243 - 246
反应条件
piperazine in N,N-dimethyl acetamide
T=150°C; Substitution; 0.5 h;
参考文献
Nishioka, Hiroyasu; Nagasawa, Masaaki; Yoshida, Kiyoshi
Synthesis, 2000 , # 2 p. 243 - 246
反应条件
potassium hydroxide; water in ethanol
6 h; Heating / reflux;
参考文献
Barber, Christopher Gordon; Bunnage, Mark Edward; Harvey, John Wilson; Mathias, John Paul
Patent: US2005/20611 A1, 2005 ;
Location in patent: Page/Page column 39 ;
反应条件
potassium hydroxide in methanol
Heating;
参考文献
Astles; Brown; Handscombe; Harper; Harris; Lewis; Lockey; McCarthy; McLay; Porter; Roach; Smith; Walsh
European Journal of Medicinal Chemistry, 1997 , vol. 32, # 5 p. 409 - 423
反应条件
1: 84 percent / KI, Bu4NCl, K2CO3 / acetone / 7 h / Heating
2: KOH / methanol / Heating
View Scheme
参考文献
Astles; Brown; Handscombe; Harper; Harris; Lewis; Lockey; McCarthy; McLay; Porter; Roach; Smith; Walsh
European Journal of Medicinal Chemistry, 1997 , vol. 32, # 5 p. 409 - 423
反应条件
1: 84 percent / KI, Bu4NCl, K2CO3 / acetone / 7 h / Heating
2: KOH / methanol / Heating
View Scheme
参考文献
Astles; Brown; Handscombe; Harper; Harris; Lewis; Lockey; McCarthy; McLay; Porter; Roach; Smith; Walsh
European Journal of Medicinal Chemistry, 1997 , vol. 32, # 5 p. 409 - 423
反应条件
methanol; potassium carbonate
参考文献
Kametani; Kano
Yakugaku Zasshi, 1952 , vol. 72, p. 1081,1083
Chem.Abstr., 1953 , p. 10536
